Recent Advances in Synthesis of Functionalized β-Lactams through Cyclization of N-Propargyl Amine/Amide Derivatives

Title:Recent Advances in Synthesis of Functionalized β-Lactams through Cyclization of N-Propargyl Amine/Amide Derivatives

Volume: 22 Issue: 2

Author(s): Esmail Vessally*, Mirzaagha Babazadeh, Akram Hosseinian, Ladan Edjlali*Lakshmaiah Sreerama*

Affiliation:

• Department of Chemistry, Payame Noor University, Tehran,Iran

• Department of Chemistry, Tabriz Branch, Islamic Azad University, Tabriz,Iran

• Department of Chemistry and Earth Sciences, College of Arts and Science, Qatar University, P.O. Box 2713, Doha,Qatar

Keywords: β-lactams, N-propargylamines, N-propargylamides, 4-exo-dig cyclization, Ugi-adducts, carbon monoxide.

Abstract: β-lactams have attracted a significant attention due to their potential biological activities and wide variety of synthetic applications. Developing novel and efficient methods for construction of functionalized β-lactams has been the subject of a number of papers in recent years. N-Propargyl amines/amides are one of the most specific class of alkynes having diverse reaction patterns. It is well known that they can undergo a number of cyclization reactions to produce various significant nitrogen containing heterocycles. This review surveys literature methods for the synthesis of highly substituted β-lactams from simple and easily available N-propargyl amine/amide derivatives from 1991 to 2017.

Cite this article as:

Vessally Esmail *, Babazadeh Mirzaagha , Hosseinian Akram , Edjlali Ladan *, Sreerama Lakshmaiah *, Recent Advances in Synthesis of Functionalized β-Lactams through Cyclization of N-Propargyl Amine/Amide Derivatives, Current Organic Chemistry 2018; 22 (2) . https://dx.doi.org/10.2174/1385272821666170519113904