Thioureas as Building Blocks for the Generation of Heterocycles and Compounds with Pharmacological Activity: An Overview

Title:Thioureas as Building Blocks for the Generation of Heterocycles and Compounds with Pharmacological Activity: An Overview

Volume: 15 Issue: 1

Author(s): Itamar Luís Goncalves, Gabriel Oliveira de Azambuja, Daniel Fabio Kawano and Vera Lucia Eifler-Lima*

Affiliation:

• Laboratorio de Sintese Organica Medicinal/LaSOM, Programa de Pos-Graduacao em Ciencias Farmaceuticas/ PPGCF, Universidade Federal do Rio Grande do Sul, Av. Ipiranga 2752, 90610-000 Porto Alegre-RS,Brazil

Keywords: Thiourea, heterocyclic synthesis, building blocks, drug design, pharmacological effects, multicomponent reactions.

Abstract: Background: Thioureas are widely used as intermediates in organic synthesis, and they are commonly used in several classes of heterocycles.

Objective: There has been an escalating interest in the development of heterocycles employing thioureas as building blocks. Furthermore, thioureas can be utilized as a reagent in a synthesis of a large number of therapeutic agents. In addition, substituted thioureas have recently gained much interest in the preparation of a wide variety of biologically active compounds.

Conclusion: This review highlights the status of thiourea scaffolds in the drug development and heterocyclic synthesis described in the literature mainly since 2010.

Cite this article as:

Goncalves Luís Itamar , de Azambuja Oliveira Gabriel , Kawano Fabio Daniel and Eifler-Lima Lucia Vera*, Thioureas as Building Blocks for the Generation of Heterocycles and Compounds with Pharmacological Activity: An Overview, Mini-Reviews in Organic Chemistry 2018; 15 (1) . https://dx.doi.org/10.2174/1570193X14666170518125219