From Tendon Injury to Collagen-based Tendon Regeneration: Overview and Recent Advances

Title:From Tendon Injury to Collagen-based Tendon Regeneration: Overview and Recent Advances

Volume: 23 Issue: 24

Author(s): Clement Rieu, Lise Picaut, Gervaise Mosser and Lea Trichet*

Affiliation:

• Laboratoire de Chimie de la Matiere Condensee de Paris, UPMC, Tour 43-44, Et. 4, 4 place Jussieu, 75252 Paris Cedex 05,France

Keywords: Tendon, injury, repair, biomaterial, graft, collagen, scaffold.

Abstract: Tendon injury is a clinical, societal and economical issue. Moreover, tendon repair represents an important clinical challenge, partly due to the mechanical constraints that occur at the junctions with muscle and bone. Several strategies have been developed for tendon repair. In this review, we first assess the importance of tendon injuries from different sites and their causes. After a short overview of tendon three-dimensional organization, the complexity of the perfect repair quest is presented ranging from current clinical procedures to new engineering scaffolds. We then sum up tendon engineering requirements and focus on new collagen-based scaffolds, which raise promising prospects to mimic and repair tendon. In particular, we survey quantitatively a large panel of techniques to produce these scaffolds, detailing their principle and recent improvements.

Cite this article as:

Rieu Clement, Picaut Lise, Mosser Gervaise and Trichet Lea *, From Tendon Injury to Collagen-based Tendon Regeneration: Overview and Recent Advances, Current Pharmaceutical Design 2017; 23 (24) . https://dx.doi.org/10.2174/1381612823666170516130515