Smart Micro/Nano-robotic Systems for Gene Delivery

Title:Smart Micro/Nano-robotic Systems for Gene Delivery

Volume: 17 Issue: 2

Author(s): Alireza Pedram and Hossein Nejat Pishkenari*

Affiliation:

• Department of Mechanical Engineering, Sharif University of Technology, P.O. Box: 11155-9567, Tehran,Iran

Keywords: Gene delivery, Micro/nano-robotics, MRI actuation, Chemotaxis, Hybrid systems, Gene release.

Abstract: Background: Small scale robotics have attracted growing attention for the prospect of targeting and accessing cell-sized sites, necessary for high precision biomedical applications and drug/gene delivery. The loss of controlled gene therapy, inducing systemic side effects and reduced therapeutic efficiency, can be settled utilizing these intelligent carriers.

Methods: Newly proposed solutions for the main challenges of control, power supplying, gene release and final carrier extraction/degradation have shifted these smart miniature robots to the point of being employed for practical applications of transferring oligonucleotides (pDNA, siRNA, mRNA, etc.) in near future.

Conclusion: In this paper, different scenarios and their endeavors to address the vital working demands and steps, in particular, carrier attachment and release, cell internalization, manipulation concerns as well as actuation systems are discussed.This review highlights some promising experimental results showing controlled gene release of robotic systems in comparison with current non-specific gene delivery methods.

Cite this article as:

Pedram Alireza and Pishkenari Nejat Hossein*, Smart Micro/Nano-robotic Systems for Gene Delivery, Current Gene Therapy 2017; 17 (2) . https://dx.doi.org/10.2174/1566523217666170511111000

DOI https://dx.doi.org/10.2174/1566523217666170511111000	Print ISSN 1566-5232
Publisher Name Bentham Science Publisher	Online ISSN 1875-5631