Gene Delivery Particle Engineering Strategies for Shape-dependent Targeting of Cells and Tissues

doi:10.2174/1566523217666170510161120

摘要

讨论：在这里，我们将讨论粒子设计中的物理参数，促进组织和细胞定向交付遗传货物。我们将讨论系统的关注，如循环，组织定位，清除，以及细胞尺度障碍，如细胞摄取和核酸包装。结论：特别是，我们将专注于工程粒子的形状和大小，以提高交付和促进精确的目标。我们还将讨论使用环境触发线索来编程或改变粒子形状的方法。

关键词: 基因传递，各向异性，纳米粒子，自组装，软光刻，形状变化。

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Current Gene Therapy

Title:Gene Delivery Particle Engineering Strategies for Shape-dependent Targeting of Cells and Tissues

Volume: 17 Issue: 2

关键词: 基因传递，各向异性，纳米粒子，自组装，软光刻，形状变化。

摘要: Background: Successful gene delivery requires overcoming both systemic and intracellular obstacles before the nucleic acid cargo can successfully reach its tissue and subcellular target location.

Materials & Methods: Non-viral mechanisms to enable targeting while avoiding off-target delivery have arisen via biological, chemical, and physical engineering strategies.

Discussion: Herein we will discuss the physical parameters in particle design that promote tissue- and cell-targeted delivery of genetic cargo. We will discuss systemic concerns, such as circulation, tissue localization, and clearance, as well as cell-scale obstacles, such as cellular uptake and nucleic acid packaging.

Conclusion: In particular, we will focus on engineering particle shape and size in order to enhance delivery and promote precise targeting. We will also address methods to program or change particle shape in situ using environmentally triggered cues.

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Gene Delivery Particle Engineering Strategies for Shape-dependent Targeting of Cells and Tissues, Current Gene Therapy 2017; 17 (2) . https://dx.doi.org/10.2174/1566523217666170510161120

DOI https://dx.doi.org/10.2174/1566523217666170510161120	Print ISSN 1566-5232
Publisher Name Bentham Science Publisher	Online ISSN 1875-5631

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