摘要
纤维化发生在各种器官中,往往对患者造成极大的伤害,甚至导致死亡。尽管在过去几十年中在纤维化领域做出了巨大努力,并对获得的纤维化反应的发病机理有了很大的了解,但仍然缺乏有效的抗纤维化治疗。越来越多的证据表明活化的可溶性鸟苷酸环化酶(sGC)具有显着的抗纤维化潜能,其强调了sGC在多种器官(包括皮肤,肾脏,肝脏和肺部)的纤维发生中的重要性。虽然sGC由于其在调节血管紧张度和血管重塑中的作用而众所周知,但其在纤维化中的可能意义仍有待阐明。近年来的新兴证据通过阻止非典型的TGF-β信号传导,提供了对sGC刺激的抗纤维化作用的新见解。在这次审查中,我们将讨论sGC及其作用机制在纤维化中的关键作用。本文中,sGC信号通路可能代表治疗组织纤维化的有希望的靶点。
关键词: 纤维化疾病,可溶性鸟苷酸环化酶,TGF-β信号通路,细胞外调节蛋白激酶,可溶性鸟苷酸环化酶调节剂,作用机制。
Current Medicinal Chemistry
Title:Soluble Guanylate Cyclase: A New Therapeutic Target for Fibrotic Diseases
Volume: 24 Issue: 29
关键词: 纤维化疾病,可溶性鸟苷酸环化酶,TGF-β信号通路,细胞外调节蛋白激酶,可溶性鸟苷酸环化酶调节剂,作用机制。
摘要: Fibrosis occurs in a variety of organs and frequently brings great harm to patients, even contributes to their death. Despite great efforts made in the field of fibrosis over the past decades and considerable understanding of the pathogenesis of fibrotic reactions attained, there is still lack of effective anti-fibrotic treatments. A growing body of evidence indicates a significant anti-fibrotic potential of activated soluble guanylate cyclase (sGC), which emphasizes the importance of sGC in fibrogenesis of diverse organs including skin, kidney, liver and lung. While sGC has been well known for its role in the regulation of vascular tone and vascular remodeling, its possible implication in fibrosis remains to be illustrated. Emerging evidence in recent years provides new insights into anti-fibrotic effect of sGC stimulation by blocking non-canonical TGF-β signaling. In this review we will discuss the key role of sGC and its mechanism of action in fibrosis. Herein, sGC signaling pathway may represent a promising target for treating tissue fibrosis.
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Cite this article as:
Soluble Guanylate Cyclase: A New Therapeutic Target for Fibrotic Diseases, Current Medicinal Chemistry 2017; 24 (29) . https://dx.doi.org/10.2174/0929867324666170509115433
DOI https://dx.doi.org/10.2174/0929867324666170509115433 |
Print ISSN 0929-8673 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-533X |
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