摘要
背景:阿尔茨海默病(AD)是一种神经退行性疾病,被认为是老年人群中慢性痴呆最常见的原因。 AD的组织病理学特征在于神经元的进行性丧失和不溶性蛋白质的沉积,其主要由淀粉样蛋白β和神经原纤维缠结(NFT)组成。 方法:几个分子过程有助于形成AD细胞标志。其中,翻译后修饰(PTM)代表了化学基团/肽与靶蛋白之间形成共价键的最有吸引力的机制,最终导致其功能发生改变。与AD有关的大多数蛋白质都经历PTM。最近的几项研究表明AD相关蛋白如APP,Aβ,tau,BACE1发生翻译后修饰。 PTM的作用有助于细胞的正常功能,尽管可能取决于许多因素的异常蛋白质修饰可以驱动发作或支持AD的发展。 结果:在这里我们将讨论几种PTM对AD相关蛋白的功能的影响,这可能有助于AD病理学的发展。 结论:我们将考虑泛素化,磷酸化,SUMO化,乙酰化和亚硝基化对特定AD相关蛋白的作用,更有趣的是,这些不同PTM之间可能发生的相互作用
关键词: 翻译后修饰,阿尔茨海默病,SUMO化,泛素化,磷酸化,亚硝基化,乙酰化
Current Alzheimer Research
Title:The Involvement of Post-Translational Modifications in Alzheimer's Disease
Volume: 15 Issue: 4
关键词: 翻译后修饰,阿尔茨海默病,SUMO化,泛素化,磷酸化,亚硝基化,乙酰化
摘要: Background: Alzheimer's disease (AD) is a neurodegenerative disorder recognized as the most common cause of chronic dementia among the ageing population. AD is histopathologically characterized by progressive loss of neurons and deposits of insoluble proteins, primarily composed of amyloid-β pelaques and neurofibrillary tangles (NFTs).
Methods: Several molecular processes contribute to the formation of AD cellular hallmarks. Among them, post-translational modifications (PTMs) represent an attractive mechanism underlying the formation of covalent bonds between chemical groups/peptides to target proteins, which ultimately result modified in their function. Most of the proteins related to AD undergo PTMs. Several recent studies show that AD-related proteins like APP, Aβ, tau, BACE1 undergo post-translational modifications. The effect of PTMs contributes to the normal function of cells, although aberrant protein modification, which may depend on many factors, can drive the onset or support the development of AD.
Results: Here we will discuss the effect of several PTMs on the functionality of AD-related proteins potentially contributing to the development of AD pathology.
Conclusion: We will consider the role of Ubiquitination, Phosphorylation, SUMOylation, Acetylation and Nitrosylation on specific AD-related proteins and, more interestingly, the possible interactions that may occur between such different PTMs.
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Cite this article as:
The Involvement of Post-Translational Modifications in Alzheimer's Disease, Current Alzheimer Research 2018; 15 (4) . https://dx.doi.org/10.2174/1567205014666170505095109
DOI https://dx.doi.org/10.2174/1567205014666170505095109 |
Print ISSN 1567-2050 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5828 |
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