Microbial Routes to (2R,3R)-2,3-Butanediol: Recent Advances and Future Prospects

Title:Microbial Routes to (2R,3R)-2,3-Butanediol: Recent Advances and Future Prospects

Volume: 17 Issue: 21

Author(s): Neng-Zhong Xie*, Xian-Rui Chen, Qing-Yan Wang, Dong Chen, Qi-Shi Du, Guo-Ping Zhou*Ri-Bo Huang*

Affiliation:

• National Engineering Research Center for Non-food Biorefinery, Guangxi Academy of Sciences, 98 Daling Road, Nanning, 530007, Guangxi,China

• National Engineering Research Center for Non-food Biorefinery, State Key Laboratory of Non-food Biomass Energy and Enzyme Technology, Guangxi Biomass Industrialization Engineering Institute, and Guangxi Key Laboratory of Biorefinery, Guangxi Academy of Sciences, No. 98 Daling Road, Nanning, 530007, Guangxi,China

• National Engineering Research Center for Non-food Biorefinery, Guangxi Academy of Sciences, 98 Daling Road, Nanning, 530007, Guangxi,China

Keywords: (2R, 3R)-2, 3-Butanediol, Microbial cell factory, Rational design, Metabolic engineering, Synthetic biology, Systematic and Integrative strategy.

Abstract: (2R,3R)-2,3-Butanediol has many industrial applications, such as it is used as an antifreeze agent and low freezing point fuel. In addition, it is particularly important to provide chiral groups in drugs. In recent years, this valuable bio-based chemical has attracted increasing attention, and significant progress has been made in the development of microbial cell factories for (2R,3R)-2,3-butanediol production. This article reviews recent advances and challenges in microbial routes to (2R,3R)-2,3- butanediol production, and highlights the metabolic engineering and synthetic biological approaches used to improve titers, yields, productivities, and optical purities. Finally, a systematic and integrative strategy for developing high-performance microbial cell factories is proposed.

Cite this article as:

Xie Neng-Zhong*, Chen Xian-Rui, Wang Qing-Yan, Chen Dong, Du Qi-Shi, Zhou Guo-Ping*, Huang Ri-Bo*, Microbial Routes to (2R,3R)-2,3-Butanediol: Recent Advances and Future Prospects, Current Topics in Medicinal Chemistry 2017; 17 (21) . https://dx.doi.org/10.2174/1568026617666170504101646