摘要
背景:开发各种胶体纳米粒子(NPs)作为诊断性探针的努力在生物医学领域一直很有希望。 具体而言,胶体金纳米粒子(GNP)由于其独特的物理化学性质和极好的生物相容性而被广泛用作分子成像和药物递送的诊断性探针。 目的:本综述概述并讨论了控制几何形状(球形,棒状和笼状)的金纳米粒子合成方法,表面官能化(共价和非共价)以及相关的体外/体内细胞毒性以及一些 有趣的诊断(成像)和治疗(光热,药物输送)应用。 结果和结论:与其他传统的治疗药物相比,GNP具有几个优势,我们坚信基于GNP的临床方法将随着创新数量的不断增加而持续受到关注。
关键词: Theranostic探针,诊断和治疗,药物输送,等离子体激元,金纳米粒子。
图形摘要
Current Drug Targets
Title:Application of Plasmonic Gold Nanoparticle for Drug Delivery System
Volume: 19 Issue: 3
关键词: Theranostic探针,诊断和治疗,药物输送,等离子体激元,金纳米粒子。
摘要: Background: Efforts in developing various colloidal nanoparticles (NPs) as theranostic probes have been promising in the biomedical field. Specifically, colloidal gold nanoparticles (GNP) have been extensively utilized as a theranostic probe for molecular imaging and drug delivery owing to their unique physiochemical properties with excellent biocompatibility.
Objective: This review outlines and discusses the progress regarding gold nanoparticle synthesis methods for controlled geometry (spherical, rod, and cage), surface functionalization (covalent and non-covalent), and associated in vitro/in vivo cytotoxicity as well as some of the interesting diagnostic (imaging) and therapeutic (photo-thermal, drug delivery) applications.
Results and Conclusion: GNP possesses several advantages compared to other traditional theranostic agents, we firmly believe that GNP based clinical approach will gain continuous interest with increasing numbers of innovations.
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Cite this article as:
Application of Plasmonic Gold Nanoparticle for Drug Delivery System, Current Drug Targets 2018; 19 (3) . https://dx.doi.org/10.2174/1389450118666170427150257
DOI https://dx.doi.org/10.2174/1389450118666170427150257 |
Print ISSN 1389-4501 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-5592 |
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