摘要
背景:白细胞介素12(IL-12)是一种多效细胞因子,在Th1型免疫应答中起着至关重要的作用。复制控制。 方法:综述了IL-12家族的结构特点及其在肿瘤中的作用。 结果:白细胞介素-12已被证明在癌症治疗中调节先天性(自然杀伤细胞)和适应性(细胞毒性T淋巴细胞)的免疫功能。这种细胞因子已被提议作为一个潜在的在肿瘤免疫治疗研究中开发的新制剂在许多动物模型中具有显著的抗肿瘤作用。此外,IL-12的抗肿瘤活性,能有效地诱导自身通过与包括抗体、抗血管生成剂、放射疗法、过继治疗和抗肿瘤疫苗在内的各种治疗方法的结合而显著改善。 结论:白细胞介素-12在肿瘤治疗中具有潜在的作用。在临床试验中使用的治疗方法的优势,最近已经报道。然而,衬底的机制IL-12及其结合的免疫调节和抗肿瘤活性仍在调查中。
关键词: 白细胞介素-12,NK细胞,肿瘤,Th1通路,受体,免疫治疗。
图形摘要
Current Cancer Drug Targets
Title:Impact of IL-12 in Cancer
Volume: 17 Issue: 8
关键词: 白细胞介素-12,NK细胞,肿瘤,Th1通路,受体,免疫治疗。
摘要: Background: Interleukin 12 (IL-12) is a pleiotropic cytokine that plays an essential role in Th1-type immune response against cancer, a condition where cells in a particular part of the body grow and reproduce uncontrollably.
Methods: In this review, we describe the structural features of IL-12 family and their roles involved in cancer.
Results: IL-12 has been demonstrated to regulate both innate (natural killer cells) and adaptive (cytotoxic T lymphocytes) immunities in cancer therapy. This cytokine has been proposed as a potential new agent to be developed in cancer immunotherapy studies due to its impressive antitumor effects in many animal models. In addition, the antitumor activity of IL-12 can be efficiently induced by itself as well as significantly improved by its combination with various treatment modalities including antibodies, antiangiogenic agents, radiotherapy, adoptive therapy, and anti-tumor vaccines.
Conclusion: IL-12 has potential roles in anticancer therapy. The advantages of using immunotherapeutic approaches in clinical trials have been reported recently. However, the mechanisms to underlay the immunoregulation and antitumor activities of IL-12 itself, as well as its combination, remain under investigation.
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Cite this article as:
Impact of IL-12 in Cancer, Current Cancer Drug Targets 2017; 17 (8) . https://dx.doi.org/10.2174/1568009617666170427102729
DOI https://dx.doi.org/10.2174/1568009617666170427102729 |
Print ISSN 1568-0096 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-5576 |
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