摘要
背景:营养对胎儿发育规划很重要。早期营养缺乏会增加许多与衰老有关的疾病,包括认知能力下降的易感性。目的:探讨早期饥荒暴露对老年人认知功能的影响。 方法:我们招募了6790名出生于1956至1964期间,中国大饥荒的发生(1959-1961)。这些受试者认知功能使用进行简易精神状态检查(MMSE)、日常生活活动量表(ADL)、工具性日常生活能力量表(IADL)、临床痴呆评定量表(CDR)。 方法:我们招募了6790名出生于1956至1964期间,中国大饥荒的发生(1959-1961)。这些受试者认知功能使用进行简易精神状态检查(MMSE)、日常生活活动量表(ADL)、工具性日常生活能力量表(IADL)、临床痴呆评定量表(CDR)。 结果:我们的研究发现,早期暴露于饥荒会显著增加以后生活中认知障碍的风险,从而导致轻度认知功能障碍(MCI)和痴呆的发病率增高。我们还发现了这种营养不良引起的性别和城乡差异。文盲、卒中史或糖尿病是促进认知功能衰退的重要危险因素。 结论:这些发现表明,在早期的生活中,包括产前和儿童期的饥荒暴露有助于老化相关的认知缺陷。
关键词: 饥荒,营养不良,早期生活,危险因素,轻度认知障碍,痴呆
Current Alzheimer Research
Title:Nutritional Deficiency in Early Life Facilitates Aging-Associated Cognitive Decline
Volume: 14 Issue: 8
关键词: 饥荒,营养不良,早期生活,危险因素,轻度认知障碍,痴呆
摘要: Background: Nutrition is important for the fetal developmental programming. Nutritional deficiency in early life could increase the susceptibility to many aging-related disorders including cognitive decline.
Objective: Our study aims to investigate the effect of early famine exposure on aging-associated cognitive function. Methods: We recruited 6790 subjects born between 1956 to 1964 during which the Great Chinese Famine occurred (1959-1961). Cognitive function of these subjects were evaluated using the Mini-Mental State Examination (MMSE), the Activities of Daily Living scale (ADL), the Instrumental Activities of Daily Living scale (IADL) and the Clinical Dementia Rating (CDR). Results: Our study identified that early exposure to the famine significantly increased the risk of cognitive impairments in later life, leading to higher prevalence of Mild Cognitive Impairment (MCI) and dementia. We also found the sex and rural-urban differences in this malnutrition-induced effect. Illiteracy, history of stroke or diabetes mellitus are great risk factors to facilitate the cognitive decline. Conclusion: These findings demonstrate that exposure to famine during early life including prenatal period and early childhood facilitates aging-associated cognitive deficits.Export Options
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Cite this article as:
Nutritional Deficiency in Early Life Facilitates Aging-Associated Cognitive Decline, Current Alzheimer Research 2017; 14 (8) . https://dx.doi.org/10.2174/1567205014666170425112331
DOI https://dx.doi.org/10.2174/1567205014666170425112331 |
Print ISSN 1567-2050 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5828 |
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