摘要
内源性抗微生物肽（AMP）是进化上的先天免疫分子因子，在宿主防御中起关键作用。由于抗药性较低，AMPs作为常规抗生素的替代品受到广泛关注。在过去几年中，已经显而易见的是，AMP的生物学功能不仅仅是直接杀死微生物细胞。该综述主要集中在相对较小的动物宿主防御肽家族中，通过二硫键稳定β-发夹结构。它们的小尺寸，刚性结构，对蛋白酶的稳定性以及过多的生物功能，包括抗菌，抗真菌，抗病毒，抗癌，内毒素结合，代谢和免疫调节活性，使天然β-发夹AMP成为药物的有吸引力的分子基础 设计。
关键词: 抗菌肽，宿主防御，先天免疫，肽治疗，β-发夹结构，二硫桥。
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