动物β-发夹抗菌肽的治疗潜力

Title:A Therapeutic Potential of Animal β-hairpin Antimicrobial Peptides

Volume: 24 Issue: 17

关键词: 抗菌肽，宿主防御，先天免疫，肽治疗，β-发夹结构，二硫桥。

摘要: Endogenous antimicrobial peptides (AMPs) are evolutionary ancient molecular factors of innate immunity that play the key role in host defense. Because of the low resistance rate, AMPs have caught extensive attention as possible alternatives to conventional antibiotics. Over the last years, it has become evident that biological functions of AMPs are beyond direct killing of microbial cells. This review focuses on a relatively small family of animal host defense peptides with the β-hairpin structure stabilized by disulfide bridges. Their small size, rigid structure, stability to proteases, and plethora of biological functions, including antibacterial, antifungal, antiviral, anticancer, endotoxin-binding, metabolism- and immune- modulating activities, make natural β-hairpin AMPs an attractive molecular basis for drug design.

Cite this article as:

A Therapeutic Potential of Animal β-hairpin Antimicrobial Peptides, Current Medicinal Chemistry 2017; 24 (17) . https://dx.doi.org/10.2174/0929867324666170424124416