New Progress in Asymmetric Synthesis of Quaternary α-Amino Acids

Title:New Progress in Asymmetric Synthesis of Quaternary α-Amino Acids

Volume: 14 Issue: 6

Author(s): Han Jiang, Yi Jin*Jun Lin*

Affiliation:

• Key Laboratory of Medicinal Chemistry for Natural Resource (Yunnan University), Ministry of Education, School of Chemical Science and Technology, Yunnan University, Kunming 650091, P.R.,China

• Key Laboratory of Medicinal Chemistry for Natural Resource (Yunnan University), Ministry of Education, School of Chemical Science and Technology, Yunnan University, Kunming 650091, P.R.,China

Keywords: Quaternary a-amino acids, asymmetric catalytic synthesis, quaternary stereocenters, formation of C-C bond, formation of C-N bond, asymmetric alkylation reaction.

Abstract: Background: Quaternary α-amino acids with a tetrasubstituted carbon stereocenter have a variety of biological activities. Due to the steric hindrance of the quaternary carbon centers, highly efficient asymmetric catalytic synthesis is greatly challenging.

Objective: In this paper, with a focus on the asymmetric formation of chemical bonds in reactions, the asymmetric catalytic synthesis of quaternary α-amino acids in recent years is reviewed.

Conclusion: Several representative catalytic asymmetric reactions are introduced, and the effects of different catalysts on the reaction results are discussed.

Cite this article as:

Jiang Han , Jin Yi *, Lin Jun *, New Progress in Asymmetric Synthesis of Quaternary α-Amino Acids, Mini-Reviews in Organic Chemistry 2017; 14 (6) . https://dx.doi.org/10.2174/1570193X14666170420121255