摘要
动脉粥样硬化是动脉粥样硬化斑块在动脉壁中发展的慢性血管疾病。相信炎症在动脉粥样硬化形成和进展中起主要作用。因此,动脉粥样硬化可以被认为是动脉血管的炎性疾病。小鼠模型证实T和B细胞缺乏可减少动脉粥样硬化病变形成中的动脉粥样硬化负担。 CD4 + T辅助细胞(Th),例如已知为动脉粥样硬化发生的小鼠模型中发现的主要CD4 + T细胞亚型的Th1细胞,增加oxLDL引起的斑块形成。 IL-17(也称为IL-17A)由T细胞或T辅助细胞的独特子集产生。产生IL-17的T细胞表达干扰素-γ(IFN-γ),这是免疫功能的重要调节因子,其在动脉粥样硬化病变中高度表达,抵抗了其作为Th17细胞的整齐特征。 Th17信号通路的调控可能在多发性和自身免疫性疾病如动脉粥样硬化的发病机制中起重要作用。在本综述中,描述了IL-17家族的结构特征及其与动脉粥样硬化有关的作用。
关键词: 动脉粥样硬化,斑块,小鼠模型,IL-17,脂蛋白,免疫功能,Th17细胞。
Current Medicinal Chemistry
Title:The Impact of IL-17 in Atherosclerosis
Volume: 24 Issue: 21
关键词: 动脉粥样硬化,斑块,小鼠模型,IL-17,脂蛋白,免疫功能,Th17细胞。
摘要: Atherosclerosis is a chronic vascular disease in which atherosclerotic plaques develop in the arterial wall. It is believed that inflammation plays a major role in atherosclerotic formation and progression. Thus, atherosclerosis can be considered as an inflammatory disease of the arterial vessel. Mouse model demonstrated that T and B cell deficiency reduces the atherosclerotic burden in the formation of an atherosclerotic lesion. CD4+ T helper cells (Th), such as Th1 cells known being the major CD4+ T cell subtype found in mouse models of atherogenesis, increase plaque formation caused by oxLDL. IL-17 (also known as IL-17A) was produced by T cells or by a unique subset of T helper cells. IL-17-producing T cells express interferon- gamma (IFN-γ), an important regulator of immune function, which is highly expressed in atherosclerotic lesions, defying their neat characteristics as Th17 cells. Regulation of Th17 signal pathway may play a significant role in the pathogenesis of multiple inflammatory and autoimmune disorders, such as atherosclerosis. In this review, the structural features of IL-17 family and their roles involved in atherosclerosis are described.
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Cite this article as:
The Impact of IL-17 in Atherosclerosis, Current Medicinal Chemistry 2017; 24 (21) . https://dx.doi.org/10.2174/0929867324666170419150614
DOI https://dx.doi.org/10.2174/0929867324666170419150614 |
Print ISSN 0929-8673 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-533X |
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