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当代阿耳茨海默病研究

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ISSN (Print): 1567-2050
ISSN (Online): 1875-5828

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Research Article

2型糖尿病患者的默认模式网络连接和相关白细胞中断与遗忘轻度认知障碍并发

卷 14, 期 11, 2017

页: [1238 - 1246] 页: 9

弟呕挨: 10.2174/1567205014666170417113441

价格: $65

摘要

背景：作为阿尔茨海默病（AD）的危险因素，2型糖尿病（T2DM）本身引起认知障碍，并具有较高的轻度认知障碍（MCI）患病率。目的：本研究的目的是探讨T2DM和遗忘性MCI（T2DM-MCI）患者的情景记忆差异，DMN功能连通性和DMN相关白质完整性与T2DM患者相比的认知。 方法：特别关注T2DM人群，我们通过休息状态功能磁共振成像对22名老年T2DM-MCI患者和24名老年T2DM患者进行了默认模式网络（DMN）的研究。这些DMN白质纤维主要包括双侧钩针，海马和钩状纤维，也与情景记忆密切相关，并对19例老年T2DM-MCI患者和23例老年T2DM患者进行扩散张量成像，对其完整性进行了研究。 结果：与T2DM患者相比，T2DM-MCI患者在情绪记忆以外的几个认知领域表现较差，左侧胰腺炎DMN功能连通性较强，左侧钙调素功能连通性较弱，且完整性降低左扣带和双侧钩状筋膜。此外，相关性分析表明，较高的左侧钙通道连通性与整体组之间更好的情景记忆性能相关。 结论：我们的研究结果表明，T2DM合并症MCI患者的功能连锁模式异常，白质完整性降低，可能作为早期发现T2DM患者的AD或AD风险生物标志物。

关键词: 2型糖尿病，轻度认知障碍，情景记忆，默认模式网络，功能连通性，白质完整性。

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