Potential Molecular Targets of Ampelopsin in Prevention and Treatment of Cancers

Title:Potential Molecular Targets of Ampelopsin in Prevention and Treatment of Cancers

Volume: 17 Issue: 12

Author(s): Xianjuan Kou, Jingjing Fan and Ning Chen*

Affiliation:

• Tianjiu Research and Development Center for Exercise Nutrition and Foods, Hubei Key Laboratory of Sport Training and Monitoring, College of Health Science, Wuhan Sports University, Wuhan 430079,China

Keywords: Natural product, ampelopsin, chemotherapy, signal pathway, molecular mechanism, cancer.

Abstract: Cancers have increased threat to human health due to the limited treatment efficacy of chemotherapy and radiotherapy with a series of toxicity and side effects; therefore, the development and utilization of natural products with potential preventive and therapeutic efficacy, and less toxicity and side effects will be beneficial to promote the health of cancer patients. In this article, the activity of ampelopsin as a natural flavonoid and its underlying molecular mechanisms for the prevention and treatments of hepatic carcinoma, breast cancer, prostate cancer and melanoma through inhibiting cell proliferation, accelerating apoptosis, inducing reactive oxygen species (ROS) generation and endoplasmic reticulum (ER) stress, suppressing angiogenesis, invasion and metastasis, and synergizing the efficacy of other anti-cancer drugs have been summarized. This study will provide a reference for the development and utilization of other natural products.

Cite this article as:

Kou Xianjuan , Fan Jingjing and Chen Ning *, Potential Molecular Targets of Ampelopsin in Prevention and Treatment of Cancers, Anti-Cancer Agents in Medicinal Chemistry 2017; 17 (12) . https://dx.doi.org/10.2174/1871521409666170412130529