Ultrasound Assisted Synthesis of Quinoline Derivatives in the Presence of SnCl2·2H2O as a Precatalyst in Water: Evaluation of their Antibacterial Activities

Title:Ultrasound Assisted Synthesis of Quinoline Derivatives in the Presence of SnCl2·2H2O as a Precatalyst in Water: Evaluation of their Antibacterial Activities

Volume: 18 Issue: 10

Author(s): A.S.G. Prasad, T. Bhaskara Rao, D. Rambabu, Mandava V. Basaveswara Rao*Manojit Pal*

Affiliation:

• Department of Chemistry, Krishna University, Machilipatnam-521001, Andhra Pradesh,India

• Dr. Reddy's Institute of Life Sciences, University of Hyderabad Campus, Hyderabad 500046,India

Keywords: Antibacterial, MCRs, quinoline, ultrasound, water, SnCl2.

Abstract: Background: SnCl2·2H2O has been used as a convenient precatalyst for the one-pot and rapid synthesis of 2-substituted quinolines under ultrasound irradiation in water. The reaction involved a 3-component reaction of aniline, aldehydes, and ethyl 3,3-diethoxypropionate in the presence of aerial oxygen to give the desired products in good yields.

Conclusion: Several of these compounds showed antibacterial activities when tested against gram-positive and gram-negative species. One compound i.e. 4b showed promising activities across both the species.

Cite this article as:

Prasad A.S.G., Rao Bhaskara T. , Rambabu D. , Rao V. Basaveswara Mandava*, Pal Manojit *, Ultrasound Assisted Synthesis of Quinoline Derivatives in the Presence of SnCl2·2H2O as a Precatalyst in Water: Evaluation of their Antibacterial Activities, Mini-Reviews in Medicinal Chemistry 2018; 18 (10) . https://dx.doi.org/10.2174/1389557517666170412112619