摘要
背景:先兆子痫是以高血压和蛋白尿为特征的二十周妊娠特征的妊娠疾病,是造成胎儿和孕产妇死亡的主要原因之一。虽然发现多种遗传和环境因素与先兆子痫风险有关,但致病途径仍未明确定义。 通过在怀孕期间进行障碍,胎儿 - 母亲交换和内分泌功能,胎盘在胎儿发育中发挥关键作用。 累积数据表明,多个长的非编码RNA(LncRNA)的表达在先兆子痫胎盘中失调。 此外,LncRNA表达的操作导致滋养层细胞培养物的功能改变,包括增殖,分化,凋亡和迁移的变化。 目的:本文回顾了关于这一主题的公布数据,并提供了有关胎盘滋养层细胞中LncRNA IGF2 / H19,MEG3,SPRY4-IT1,HOTAIR,MALAT1,FLT1P1和CEACAMP8的调节和功能的详细信息。 还讨论了这些LncRNA作用的潜在机制,以便于更好地了解这些LncRNA对先兆子痫发病机制的潜在作用。结论:阐述了一些lncRNA可能通过甲基化,Notch-EGFL7信号通路和Wnt /β-连环蛋白途径促进先兆子痫的发病机制。
关键词: 先兆子痫,非编码RNA,LncRNA,滋养层,胎盘,发病机制
图形摘要
Current Drug Targets
Title:Dysregulation of LncRNAs in Placenta and Pathogenesis of Preeclampsia
Volume: 18 Issue: 10
关键词: 先兆子痫,非编码RNA,LncRNA,滋养层,胎盘,发病机制
摘要: Background: Preeclampsia, a gestational disease characterized by hypertension and proteinuria twenty weeks into pregnancy, is one of the leading causes of fetal and maternal mortality. Although multiple genetic and environmental factors are found to be related to the preeclampsia risk, the pathogenic pathways remain largely undefined. The placenta plays a critical role in the fetal development by carrying out the barrier, fetal-maternal exchange, and endocrine functions during pregnancy. Accumulated data indicated that the expression of multiple long noncoding RNA (LncRNA) is dysregulated in preeclamptic placentas. Moreover, manipulation of LncRNA expression led to functional alterations in trophoblast cell cultures, including changes in proliferation, differentiation, apoptosis, and migration.
Objective: This article reviews published data on this subject and provides detailed information on the regulation and function of LncRNAs IGF2/H19, MEG3, SPRY4-IT1, HOTAIR, MALAT1, and FLT1P1 and CEACAMP8 in placental trophoblasts. The potential mechanisms underlying the action of these LncRNAs are also discussed to facilitate a better understanding on the potential role of these LncRNAs for the pathogenesis of preeclampsia. Conclusion: It is elaborated that some lncRNAs probably contribute to the pathogenesis of preeclampsia through methylation, Notch-EGFL7 signaling pathway and Wnt/β-catenin pathway.Export Options
About this article
Cite this article as:
Dysregulation of LncRNAs in Placenta and Pathogenesis of Preeclampsia, Current Drug Targets 2017; 18 (10) . https://dx.doi.org/10.2174/1389450118666170404160000
DOI https://dx.doi.org/10.2174/1389450118666170404160000 |
Print ISSN 1389-4501 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-5592 |
Related Journals
Related Books
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
PPARγ: Potential Therapeutic Target for Ailments Beyond Diabetes and its Natural Agonism
Current Drug Targets Insulin Resistance, Obesity and the Metabolic Syndrome. Is there a Therapeutic Role for Endothelin-1 Antagonists?
Current Vascular Pharmacology Evidence for the Involvement of Resistin in Inflammation and Cardiovascular Disease
Current Diabetes Reviews Determination of Mercury in Iron Supplement Using Slurry Sampling and Cold Vapor Atomic Absorption Spectrometry
Current Analytical Chemistry Improvement in Hypertension Management with Pharmacological and Non- Pharmacological Approaches: Current Perspectives
Current Pharmaceutical Design Systemic DNA Damage Response and Metabolic Syndrome as a Premalignant State
Current Molecular Medicine S-nitrosation/Denitrosation in Cardiovascular Pathologies: Facts and Concepts for the Rational Design of S-nitrosothiols
Current Pharmaceutical Design Editorial [Hot topic: Targets of Research in the Metabolic Syndrome (Guest Editor: Lindsay Brown)]
Endocrine, Metabolic & Immune Disorders - Drug Targets The Autocrine/Paracrine Loop After Myocardial Stretch: Mineralocorticoid Receptor Activation
Current Cardiology Reviews Adherence to Cardiac Practice Guidelines in the Management of Non-ST-Elevation Acute Coronary Syndromes: A Systematic Literature Review
Current Cardiology Reviews Evaluation of Ischemic Heart Disease Factors in Hemophilia Patients in Khorramabad
Cardiovascular & Hematological Disorders-Drug Targets Immunomodulation in Inflammatory Neuropathies: Rationale and Safety
Current Drug Safety Peculiaritie of Distribution of Polymorphic Variants of IL1Β Gene in Patients with Atherosclerosis and Metabolic Syndrome
Current Pharmacogenomics and Personalized Medicine Metalloprotein Inhibitors for the Treatment of Human Diseases
Current Topics in Medicinal Chemistry Use of Chronic Disease Registries to Optimize Cardiovascular Health
Current Vascular Pharmacology Anti-obesity Agents: A Focused Review on the Structural Classification of Therapeutic Entities
Current Topics in Medicinal Chemistry Relation of Obesity to Cognitive Function: Importance of Central Obesity and Synergistic Influence of Concomitant Hypertension. The Framingham Heart Study
Current Alzheimer Research Proteolytic Activity of Oenococcus oeni Enables the Increase in Antioxidant and Antihypertensive Activities from Wine
Current Pharmaceutical Biotechnology Epigenetic control of cardiovascular health by nutritional polyphenols involves multiple chromatin-modifying writer-reader-eraser proteins
Current Topics in Medicinal Chemistry Chronic Diseases and COVID-19: A Review
Endocrine, Metabolic & Immune Disorders - Drug Targets