血清HE4水平作为预测妇科癌症复发的生物标志物

Title:Serum HE4 Level as a Biomarker to Predict the Recurrence of Gynecologic Cancers

Volume: 18 Issue: 10

关键词: HE4，妇科癌症，卵巢癌，子宫内膜癌，癌症复发，预后。

摘要: Background: HE4 may be a valuable early indicator of the recurrence of gynecologic cancers. Numerous studies have shown that high expression levels of serum HE4 correlate with ovarian and endometrial cancer recurrence. High HE4 levels may be an independent factor to predict these cancers’ poor prognosis.

Objective: This literature review investigates the relationship between serum HE4 levels and the recurrence of ovarian and endometrial cancer.

Conclusion: HE4 displays malignant behavior by promoting cancer cells to skip from G1 phase to S phase, maintaining cell viability, encouraging cell proliferation, inhibiting cell apoptosis, and increasing resistance to drug treatments. Further studies are required to verify that elevated serum HE4 levels correlate with the recurrence of ovarian and endometrial cancer.

Cite this article as:

Serum HE4 Level as a Biomarker to Predict the Recurrence of Gynecologic Cancers, Current Drug Targets 2017; 18 (10) . https://dx.doi.org/10.2174/1389450118666170404154929

DOI https://dx.doi.org/10.2174/1389450118666170404154929	Print ISSN 1389-4501
Publisher Name Bentham Science Publisher	Online ISSN 1873-5592