抗癌药物开发前景指标：近期动态

Title:Promising Targets in Anti-cancer Drug Development: Recent Updates

Volume: 24 Issue: 42

关键词: 抗癌剂，微管蛋白抑制剂，激酶，癌症干细胞，多药耐药性，多靶向药物。

摘要: Cancer is a multifactorial disease and its genesis and progression are extremely complex. The biggest problem in the anticancer drug development is acquiring of multidrug resistance and relapse. Classical chemotherapeutics directly target the DNA of the cell, while the contemporary anticancer drugs involve molecular-targeted therapy such as targeting the proteins possessing abnormal expression inside the cancer cells. Conventional strategies for the complete eradication of the cancer cells proved ineffective. Targeted chemotherapy was successful in certain malignancies however, the effectiveness has often been limited by drug resistance and side effects on normal tissues and cells. Since last few years, many promising drug targets have been identified for the effective treatment of cancer. The current review article describes some of these promising anticancer targets that include kinases, tubulin, cancer stem cells, monoclonal antibodies and vascular targeting agents. In addition, promising drug candidates under various phases of clinical trials are also described. Multi-acting drugs that simultaneously target different cancer cell signaling pathways may facilitate the process of effective anti-cancer drug development.

Cite this article as:

Promising Targets in Anti-cancer Drug Development: Recent Updates, Current Medicinal Chemistry 2017; 24 (42) . https://dx.doi.org/10.2174/0929867324666170331123648