摘要
多发性骨髓瘤(MM)是不可治愈的血浆细胞瘤,占所有血液恶性肿瘤的约10%。最近,新出现的证据表明MM细胞和浸润性免疫细胞之间的骨髓相互作用的复杂性已被报道可促进肿瘤细胞的增殖,存活和耐药性。微小RNA(miRNA)是在细胞中具有调节功能的小的非编码RNA分子,其表达在不同恶性肿瘤中具有预测和预后价值。由于它们通过不同机制使免疫反应极化的能力,包括免疫细胞的分子重编程,MiRNA正在越来越受到关注。这一特征与miRNA模拟物或抑制剂的抗肿瘤活性一起使得miRNA网络成为新型抗MM治疗方法的有吸引力的研究领域。在这篇综述中,我们将讨论MM细胞与骨髓宿主免疫细胞间相互作用的最新进展,特别关注miRNA网络调制引起的分子和功能变化。我们终将指出治疗干预的潜在目标。
关键词: MicroRNA,miRNA,多发性骨髓瘤,免疫治疗,肿瘤免疫学,免疫反应。
图形摘要
Current Cancer Drug Targets
Title:Immunomodulatory Activity of MicroRNAs: Potential Implications for Multiple Myeloma Treatment
Volume: 17 Issue: 9
关键词: MicroRNA,miRNA,多发性骨髓瘤,免疫治疗,肿瘤免疫学,免疫反应。
摘要: Multiple myeloma (MM) is an incurable plasma cell neoplasm accounting for about 10% of all hematologic malignancies. Recently, emerging evidence is disclosing the complexity of bone marrow interactions between MM cells and infiltrating immune cells, which have been reported to promote proliferation, survival and drug resistance of tumor cells. MicroRNAs (miRNAs) are small non-coding RNA molecules with regulatory functions in the cell, whose expression has predictive and prognostic value in different malignancies. MiRNAs are gaining increasing interest due to their capability to polarize the immune-response through different mechanisms, which include the molecular reprogramming of immune cells. This characteristic, together with the antitumor activity of miRNA mimics or inhibitors, make the miRNA network an attractive area of investigation for novel anti-MM therapeutic approaches. In this review, we will discuss the recent advances in the understanding of the interplay between MM cells and bone marrow resident immune cells, with special focus on the molecular and functional changes induced by miRNA network modulation. We will finally indicate potential targets for therapeutic intervention.
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Cite this article as:
Immunomodulatory Activity of MicroRNAs: Potential Implications for Multiple Myeloma Treatment, Current Cancer Drug Targets 2017; 17 (9) . https://dx.doi.org/10.2174/1568009617666170330154756
DOI https://dx.doi.org/10.2174/1568009617666170330154756 |
Print ISSN 1568-0096 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-5576 |
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