Role of Chirality in Drugs: An Overview

Hourieh        Alkadi; Rajwa        Jbeily

doi:10.2174/1871526517666170329123845

Abstract

Stereochemistry has occupied a great role in the manufacture and development of pharmaceuticals. Chiral properties play an important role in the determination of pharmacological actions of the drug. In recent years, there is a considerable interest in chiral separation to isolate and examine both enantiomers. This article provides an overview about the stereochemistry and its role in drugs, and also, offers approved isolation methods for enantiomeric pairs.

Keywords: Chirality, stereoisomer, enantiomer, pharmacology, chiral separation, chiral drug.

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Infectious Disorders - Drug Targets

Title:Role of Chirality in Drugs: An Overview

Volume: 18 Issue: 2

Author(s): Hourieh Alkadi*Rajwa Jbeily

Affiliation:

Department of Pharmaceutical Chemistry & Drug Control, Faculty of Pharmacy, Arab International University,Syrian Arab Republic

Keywords: Chirality, stereoisomer, enantiomer, pharmacology, chiral separation, chiral drug.

Abstract: Stereochemistry has occupied a great role in the manufacture and development of pharmaceuticals. Chiral properties play an important role in the determination of pharmacological actions of the drug. In recent years, there is a considerable interest in chiral separation to isolate and examine both enantiomers. This article provides an overview about the stereochemistry and its role in drugs, and also, offers approved isolation methods for enantiomeric pairs.

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Alkadi Hourieh *, Jbeily Rajwa , Role of Chirality in Drugs: An Overview, Infectious Disorders - Drug Targets 2018; 18 (2) . https://dx.doi.org/10.2174/1871526517666170329123845

DOI https://dx.doi.org/10.2174/1871526517666170329123845	Print ISSN 1871-5265
Publisher Name Bentham Science Publisher	Online ISSN 2212-3989