视网膜生物标志物在早期阿尔茨海默病中早期诊断和预后的潜力

Title:Diagnostic and Prognostic Potential of Retinal Biomarkers in Early On-Set Alzheimer’s Disease

Volume: 14 Issue: 9

关键词: 阿尔茨海默病，β淀粉样蛋白，生物标志物，早期诊断，视网膜，视网膜成像。

摘要: Objective: Accumulating evidence suggests that the eye can be used in the assessment of early on-set Alzheimer’s disease (AD). The eye offers a natural window to the brain through the retina. The retina and brain share common developmental origins and patho-physiological origins and mechanisms, having been sequestered from it during early development, but retaining its connections with the brain via the optic nerve. Therefore, it is well understood that neurological abnormalities have a direct profound impact on the retina. Recent studies suggest an array of physiological and pathological changes in the retina in dementia and specifically in AD. There are also reports on imaging the two hallmark proteins of the disease, extracellular amyloid beta peptides and intracellular hyper phosphorylated tau protein, as a proxy to neuroimaging.

Cite this article as:

Diagnostic and Prognostic Potential of Retinal Biomarkers in Early On-Set Alzheimer’s Disease, Current Alzheimer Research 2017; 14 (9) . https://dx.doi.org/10.2174/1567205014666170329114445