摘要
背景:在过去的二十年中,深海真菌被认为是药物研发的药理活性次级代谢产物的新来源,主要基于深海独特性会产生同样史无前例的天然产物。 实际上,到目前为止,已经从深海真菌中鉴定了200多种新的代谢物,这是支持上述说法的。 结果:本综述总结了过去六年(2010年 - 2016年10月)来自深部真菌的新型和/或生物活性化合物,并批判性评估迄今为止公布的数据是否真的支持这些真菌是 新的生物活性化学实体。
关键词: 深海真菌,极端微生物,天然产物,生物活性代谢物,药物发现,生物勘探。
Current Medicinal Chemistry
Title:Natural Products from Deep-Sea-Derived Fungi ̶ A New Source of Novel Bioactive Compounds?
Volume: 25 Issue: 2
关键词: 深海真菌,极端微生物,天然产物,生物活性代谢物,药物发现,生物勘探。
摘要: Background: Over the last two decades, deep-sea-derived fungi are considered to be a new source of pharmacologically active secondary metabolites for drug discovery mainly based on the underlying assumption that the uniqueness of the deep sea will give rise to equally unprecedented natural products. Indeed, up to now over 200 new metabolites have been identified from deep-sea fungi, which is in support of the statement made above.
Results: This review summarizes the new and/or bioactive compounds reported from deepsea- derived fungi in the last six years (2010 – October 2016) and critically evaluates whether the data published so far really support the notion that these fungi are a promising source of new bioactive chemical entities.
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Cite this article as:
Natural Products from Deep-Sea-Derived Fungi ̶ A New Source of Novel Bioactive Compounds?, Current Medicinal Chemistry 2018; 25 (2) . https://dx.doi.org/10.2174/0929867324666170314150121
DOI https://dx.doi.org/10.2174/0929867324666170314150121 |
Print ISSN 0929-8673 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-533X |
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