摘要
背景:阿尔茨海默病(AD)是老年人最常见的神经退行性痴呆,是全球老年人丧失能力和依赖他人的主要慢性疾病。临床上,AD的特征是进行性认知衰退,这干扰了执行日常生活活动的能力。手写和绘画是复杂的人类活动,需要复杂的认知,动觉和感知运动特征。 目的:比较AD患者与轻度认知障碍患者(MCI)和健康对照组之间手写和绘图的运动学特征。 方法:我们使用横截面和观察设计来评估使用计算机化系统的手写和绘图的运动和压力特征。 要求参与者复制一个句子,写一个指定句子和自己写的一个句子,复制二维三维图纸,并执行时钟绘图测试。 通过判别分析,我们探索了几种运动特征的价值,以便根据他们的认知功能程度对参与者进行分类。 结果:样本由52名参与者(23名AD,12名MCI和17名健康对照组成),平均年龄69.7岁(SD = 8.11)。 正确分类的程度在很大程度上取决于被分类群体的性质和具体任务,范围在63.5%到100%之间。 基于运动学测量的诊断准确性显示出更高的特异性值,用于区分正常和受损认知(MCI和AD),并且在区分受损认知水平(MCI与AD)时获得较高的灵敏度。 结论:写作和绘图程序只是代表了运动特征,而不是最终的结果,还需要有用和客观的的认知障碍患者临床评估补充。
关键词: 阿尔茨海默病,轻度认知障碍,运动学,手写,痴呆,记忆力丧失。
Current Alzheimer Research
Title:Kinematic and Pressure Features of Handwriting and Drawing: Preliminary Results Between Patients with Mild Cognitive Impairment, Alzheimer Disease and Healthy Controls
Volume: 14 Issue: 9
关键词: 阿尔茨海默病,轻度认知障碍,运动学,手写,痴呆,记忆力丧失。
摘要: Background: Alzheimer’s disease (AD) is the most common neurodegenerative dementia of old age, and the leading chronic disease contributor to disability and dependence among older people worldwide. Clinically, AD is characterized by a progressive cognitive decline that interferes with the ability to perform the activities of daily living. Handwriting and drawing are complex human activities that entail an intricate blend of cognitive, kinesthetic, and perceptual-motor features.
Objective: To compare the kinematic characteristics of handwriting and drawing between patients with AD, patients with mild cognitive impairment (MCI) and healthy controls. Methods: We used a cross-sectional and observational design to assess the kinematic and pressure features of handwriting and drawing using a computerized system. Participants were asked to copy one sentence, write a dictated sentence and an own sentence, copy two and-three dimensions drawings, and to execute the clock drawing test. By means of discriminant analyses, we explored the value of several kinematic features in order to classify participants depending on their degree of cognitive functioning. Results: The sample consisted of 52 participants (23 AD, 12 MCI, and 17 healthy controls) with a mean age of 69.7 years (SD=8.11). The degree of correct classification was largely dependent on the nature of the groups to be classified and the specific task, and ranged between 63.5% and 100%. Diagnostic accuracy based on kinematic measures showed higher specificity values for distinguishing between normal and impaired cognition (MCI and AD), and higher sensitivity was obtained when distinguishing between impaired cognition levels (MCI vs. AD). Conclusion: The kinematic features of writing and drawing procedures, rather than the final product, may be a useful and objective complement to the clinical assessment of patients with cognitive impairment.Export Options
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Cite this article as:
Kinematic and Pressure Features of Handwriting and Drawing: Preliminary Results Between Patients with Mild Cognitive Impairment, Alzheimer Disease and Healthy Controls, Current Alzheimer Research 2017; 14 (9) . https://dx.doi.org/10.2174/1567205014666170309120708
DOI https://dx.doi.org/10.2174/1567205014666170309120708 |
Print ISSN 1567-2050 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5828 |
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Neuroinflammation is an invariable hallmark of chronic and acute neurodegenerative disorders and has long been considered a potential drug target for Alzheimer?s disease (AD) and dementia. Significant evidence of inflammatory processes as a feature of AD is provided by the presence of inflammatory markers in plasma, CSF and postmortem brain ...read more
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