Abstract
Having demonstrated that nonsymmetric cephalostatin analogues are superior in biological activity to their symmetric counterparts we here report on further possibilities for desymmetrization of the readily available diketone 4. Since monoenolates had been prepared at an earlier stage, we describe here the selectivity of phenyl-iodosyldiacetate oxidations under basic conditions and as an example of selective nucleophilic attack, the Wittigmethylenation at the 12-ketogroup followed by a hydroboration is documented.
Keywords: nonsymmetric cephalostatin analogous, desymmetrization Reactions, monoenolates, phenyl-iodosyldiacetate oxidations
Call for Papers in Thematic Issues
Catalytic C-H bond activation as a tool for functionalization of heterocycles
The major topic is the functionalization of heterocycles through catalyzed C-H bond activation. The strategies based on C-H activation not only provide straightforward formation of C-C or C-X bonds but, more importantly, allow for the avoidance of pre-functionalization of one or two of the cross-coupling partners. The beneficial impact of ...read more
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