摘要
背景:在过去二十年中,早期发现脑肿瘤的技术进步显着。 然而,在多形性成胶质细胞瘤(GBM)的治疗中没有观察到显着的改善,其是最常见的脑肿瘤加上最差的预后。 GBM的特征在于对广泛的抗肿瘤药物具有广泛的抗性。 该属性是称为多药耐药(MDR)的现象的结果,其显着限制了非侵入性替代疗法。 这种限制主要是由于ABC转运蛋白和与DNA修复相关的蛋白质如MGMT酶的活性。 由于GBM患者的死亡率高,目前的治疗缺陷,这种新型肿瘤的治疗策略至关重要。方法:本文综述了GBM治疗方案,包括使用烷化剂与MGMT抑制剂,MDR调节剂和免疫疗法。 我们将我们的书目研究集中在包含过去20年发表的体外,体内和临床阶段分析的论文中。 结果:使用烷化剂加MGMT抑制剂的几项研究已经证明了良好的效果,尽管生存率没有很大改善。 使用ABC转运蛋白的调节剂增强化疗的作用,证明它是有效的补充疗法。 免疫疗法作为GBM治疗的有针对性和个性化方法已经发生了重大进展。 结论:本评论中讨论的替代补体疗法的使用可能会增加GBM患者的生存率; 然而,需要额外的临床阶段分析和新的治疗方案的产生。
关键词: 多形性成胶质细胞瘤,烷化剂,MGMT,多重耐药性,MRP-1,免疫治疗。
Current Medicinal Chemistry
Title:Current Therapeutic Alternatives and New Perspectives in Glioblastoma Multiforme
Volume: 24 Issue: 25
关键词: 多形性成胶质细胞瘤,烷化剂,MGMT,多重耐药性,MRP-1,免疫治疗。
摘要: Background: In the last two decades, there have been significant technological advances in the early detection of brain tumors. However, no notable improvements have been observed in the treatment of Glioblastoma Multiforme (GBM), the most common brain neoplasm coupled with the worst prognosis. GBM is characterized by an extensive resistance to a broad spectrum of anti-tumor drugs. This property is the result of a phenomenon known as Multiple Drug Resistance (MDR), which significantly limits noninvasive alternative therapies. This limitation is primarily due to the activity of ABC transporters and proteins related with DNA repair such as the MGMT enzyme. Due to the high mortality rate in GBM patients and current treatment deficits, new therapeutic strategies for this type of neoplasm are of vital importance.
Methods: In this review, proposed treatments for GBM, including the use of alkylating agents with MGMT inhibitors, MDR modulators, and immunotherapies are discussed. We focused our bibliographic research on papers containing in vitro, in vivo, and clinical phase analysis published over the last 20 years. Results: Several studies have demonstrated good results using alkylating agents plus MGMT inhibitors, although without great improvements in survival. The use of modulators of ABC transporters enhances the effects of chemotherapy, proving it an effective complementary therapy. Immunotherapies have undergone significant developments as a directed and personalized approach for GBM treatment. Conclusion: The use of alternative complementary therapies discussed in this review could increase the survival of GBM patients; however, additional clinical phase analysis and the generation of new treatment protocols are required.Export Options
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Cite this article as:
Current Therapeutic Alternatives and New Perspectives in Glioblastoma Multiforme, Current Medicinal Chemistry 2017; 24 (25) . https://dx.doi.org/10.2174/0929867324666170303122241
DOI https://dx.doi.org/10.2174/0929867324666170303122241 |
Print ISSN 0929-8673 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-533X |
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