摘要
Hepsin是一种在细胞生长发育中发挥关键作用的II型跨膜丝氨酸蛋白酶（TTSP）。 Hepin在前列腺癌（PCa）中高度表达，与其进展和转移相关。因此，它被认为是PCa的有吸引力的生物标志物。近来，已经开发了针对hepsin的低分子量抑制剂。基于关键的化学支架，它们可以分为四类：吲哚甲酰胺，苯甲酰胺，基于肽的类似物和2,3-二氢-1H-伴侣二胺。在这次审查中，我们讨论了四种类型的蛋白酶抑制剂的设计策略，结构 - 活性关系（SAR）和结合模式
关键词: Hepsin，前列腺癌，II型跨膜丝氨酸蛋白酶，结构活性关系（SAR），脒，肽。
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