Abstract
Background: Corticotropin releasing hormone (CRH), the main peptide-mediator of stress, has been found in the female reproductive system.
Objective: Herein, the role of CRH receptors in the female reproductive system is presented.
Results: It is clear that CRH receptors are involved in the regulation of the hypothalamic-pituitaryovarian axis, while locally are associated with decidualization, embryonic implantation, early fetal development and triggering of parturition.
Conclusion: Abnormal CRH signaling may contribute to obstetrical pathophysiology, such as preeclampsia, abnormal placenta invasion, endometrial growth retardation and preterm delivery.
Keywords: CRH receptors, ovary, implantation, fetal immunotolerance, receptivity, parturition.
Graphical Abstract
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