Amino-functional Silsesquioxanes (POSS)-Effective Glass Surface Modifiers in Solidphase Nucleic Acid Synthesis

Title:Amino-functional Silsesquioxanes (POSS)-Effective Glass Surface Modifiers in Solidphase Nucleic Acid Synthesis

Volume: 21 Issue: 25

Author(s): Karol Szubert, Marta Piepiorka, Magdalena Jankowska-Wajda, Jolanta Brzezinska, Karol Pasternak, Natalia Remszel, Emilia Frydrych-Tomczak, Hieronim Maciejewski and Marcin K. Chmielewski*

Affiliation:

• Institute of Bioorganic Chemistry, Polish Academy of Sciences, Noskowskiego 12/14, PL-61704 Poznan,Poland

Keywords: Silsesquioxane, solid-phase synthesis, nucleic acids, RNA or DNA synthesis, solid supports, scanning electron microscopy.

Abstract: Branched amino functional polyoctahedral silsesquioxanes (POSS) were prepared by using different stoichiometric ratios of two olefins: allylamine and vinyltrimethoxysilane. Amino-rich CPG particles were produced by direct silanisation with amino-POSS silanes. The parameters of surface morphology (total volume and size of pores) of the obtained supports were determined by Brunauer-Emmett-Teller method. Results from Scanning Electron Microscopy show that there is no alteration in surface chemistry and only modest changes in mechanical properties are detected. The POSS-modified CPG supports were demonstrated as effective scaffolds for the chemical synthesis of nucleic acids.

Cite this article as:

Szubert Karol, Piepiorka Marta, Jankowska-Wajda Magdalena, Brzezinska Jolanta, Pasternak Karol, Remszel Natalia, Frydrych-Tomczak Emilia, Maciejewski Hieronim and Chmielewski K. Marcin*, Amino-functional Silsesquioxanes (POSS)-Effective Glass Surface Modifiers in Solidphase Nucleic Acid Synthesis, Current Organic Chemistry 2017; 21 (25) . https://dx.doi.org/10.2174/1385272821666170222111024