降低HoxD10的表达促进前列腺癌增生性和侵略性的表型

Title:Decreased HoxD10 Expression Promotes a Proliferative and Aggressive Phenotype in Prostate Cancer

Volume: 17 Issue: 1

关键词: 前列腺癌，HoxD10基因，免疫组织化学，增生，侵袭性表型，生化无复发生存、发展。

摘要: HoxD10 gene plays a critical role in cell proliferation in the process of tumor development. However, the protein expression level and the function of HoxD10 in prostate cancer remain unknown. Using tissue microarray, we demonstrate that the protein expression of HoxD10 is commonly decreased in prostate cancer tissues (n = 92) compared to adjacent benign prostate tissues (n = 77). Functionally, knockdown of HoxD10 resulted in significant promotion of prostate cancer cell proliferation. Moreover, knockdown of HoxD10 strikingly stimulated prostate tumor growth in a mouse xenograft model. We also found a significant association between decreased immunohistochemical staining of HoxD10 expression and higher Gleason score (P = 0.031) and advanced clinical pathological stage (P = 0.011). An analysis of the Taylor database revealed that decreased HoxD10 expression predicted worse biochemical recurrence (BCR)-free survival of PCa patients (P = 0.005) and the multivariate analyses further supported that HoxD10 might be an independent predictor for BCR-free survival (P = 0.027). Collectively, our data suggest that the loss of HoxD10 function is common and may thus result in a progressive phenotype in PCa. HoxD10 may function as a biomarker that differentiates patients with BCR disease from the ones that are not after radical prostatectomy, implicating its potential as a therapeutic target.

Cite this article as:

Decreased HoxD10 Expression Promotes a Proliferative and Aggressive Phenotype in Prostate Cancer, Current Molecular Medicine 2017; 17 (1) . https://dx.doi.org/10.2174/1566524017666170220104920