Abstract
Meldrum's acid, a white solid which was prepared for the first time by Andrew Norman in 1908, is a versatile and efficient motif in chemistry. The rigid structure, low steric hindrance, in addition with high acidity of the C5–H, are some unique chemical properties of this O-containing heterocycle. Several organic compounds based on Meldrum's acid have interesting applications in biology, industry and drugs. Its special structure makes it a good target for both nucleophilic as well as electrophilic attack. Preparation of different forms of these scaffolds, with a glance on the reaction media, has been reviewed. In addition, other part of the manuscript is based on heat and solvent of the reaction media. These factors focused on green chemistry rules. This review classified the multi-component transformations of Meldrum's acid as one of their substrates with respect to these two important aspects of green synthesis up to middle of 2016.
Keywords: Meldrum's acid, multi-component, aqueous media, solvent-free, Knoevenagel condensation, room temperature.
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Current Organic Chemistry
Title:Meldrum's Acid in Organic Synthesis, an Outlook to Reaction Media
Volume: 21 Issue: 12
Author(s): Kobra Nikoofar*Yeganeh Shahedi
Affiliation:
- Department of Chemistry, Faculty of Physics and Chemistry, Alzahra University, Vanak, P.O. Box 1993893973, Tehran,Iran
Keywords: Meldrum's acid, multi-component, aqueous media, solvent-free, Knoevenagel condensation, room temperature.
Abstract: Meldrum's acid, a white solid which was prepared for the first time by Andrew Norman in 1908, is a versatile and efficient motif in chemistry. The rigid structure, low steric hindrance, in addition with high acidity of the C5–H, are some unique chemical properties of this O-containing heterocycle. Several organic compounds based on Meldrum's acid have interesting applications in biology, industry and drugs. Its special structure makes it a good target for both nucleophilic as well as electrophilic attack. Preparation of different forms of these scaffolds, with a glance on the reaction media, has been reviewed. In addition, other part of the manuscript is based on heat and solvent of the reaction media. These factors focused on green chemistry rules. This review classified the multi-component transformations of Meldrum's acid as one of their substrates with respect to these two important aspects of green synthesis up to middle of 2016.
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Cite this article as:
Nikoofar Kobra*, Shahedi Yeganeh, Meldrum's Acid in Organic Synthesis, an Outlook to Reaction Media, Current Organic Chemistry 2017; 21 (12) . https://dx.doi.org/10.2174/1385272821666170215091408
DOI https://dx.doi.org/10.2174/1385272821666170215091408 |
Print ISSN 1385-2728 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5348 |
Call for Papers in Thematic Issues
Catalytic C-H bond activation as a tool for functionalization of heterocycles
The major topic is the functionalization of heterocycles through catalyzed C-H bond activation. The strategies based on C-H activation not only provide straightforward formation of C-C or C-X bonds but, more importantly, allow for the avoidance of pre-functionalization of one or two of the cross-coupling partners. The beneficial impact of ...read more
Chemistry and Biology of Carbohydrates
Carbohydrates are one of the most abundant natural products and are considered to be extremely important biomolecules for their ever-increasing impact on chemistry and biology. Their role in several important biological processes, notably energy storage, transport, modulation of protein function, intercellular adhesion, malignant transformation, signal transduction, viral, and bacterial cell ...read more
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