在胃肠道通路中维生素D和肿瘤干细胞

Title:Vitamin D and Cancer Stem Cells in the Gastrointestinal Tract

Volume: 24 Issue: 9

关键词: 维生素D， 胃肠道癌症，癌症干细胞，癌症干细胞标记物，癌症微环境

摘要: Vitamin D has been widely used as a dietary supplement for the prevention and treatment of bone disorders. Epidemiological and preclinical studies demonstrated the anticancer action of vitamin D in a variety of cancers including those in the gastrointestinal (GI) tract. In these studies the inhibitory action of vitamin D on cancer stem cells (CSCs) has been a focus and is also an important subject to revolutionize the therapeutic potential of vitamin D on cancer treatment. Here, we summarize the involvement of CSC markers and factors and also their signaling pathways in the development of cancers in the esophagus, stomach, colon, pancreas and also liver. It is also evidenced that vitamin D could inhibit these markers and factors and their related signaling pathways to suppress tumor progression. All these information could provide new strategies in repurposing vitamin D as therapeutic agent to inhibit cancers in the GI tract.

Cite this article as:

Vitamin D and Cancer Stem Cells in the Gastrointestinal Tract, Current Medicinal Chemistry 2017; 24 (9) . https://dx.doi.org/10.2174/0929867324666170214110633