摘要
背景:胰腺癌(PC)的发病率在上升的同时,这种恶性疾病造成的死亡,很大程度上是由于现有治疗策略的有限改进。尽管进行了积极的pc研究,但在过去30年中,这种癌症的5年生存率没有明显改善。与许多其他癌症一样,正常胰腺细胞需要数年才能转化为胰腺前病变,并进一步发展为浸润性癌。目的:胰腺癌的化学预防。方法:回顾已有文献。结果与结论:多种基因工程小鼠(GEM)模型的可获得性导致了对该病的认识加快,而干预策略的制定则拖延了很长一段时间。这些GEM模型自发地逐步发展PC,并模仿人类的疾病病因学。了解PC从起始到进展到转移的发展过程,对于早期发现和预防PC有着重要的意义。在本综述中,我们将重点介绍胰腺癌的现状、潜在的挑战、现有战略的进展和可利用的机会,并就胰腺癌化学预防这一日益重要的领域内的关键研究领域提出建议。
关键词: 胰腺癌,化学预防,转基因小鼠模型,早期检测,靶点,药物,侵袭性癌。
Current Medicinal Chemistry
Title:Current Challenges and Opportunities for Chemoprevention of Pancreatic Cancer
Volume: 25 Issue: 22
关键词: 胰腺癌,化学预防,转基因小鼠模型,早期检测,靶点,药物,侵袭性癌。
摘要: Background: The incidence of pancreatic cancer (PC) is rising in parallel with the deaths caused by this malignant disease largely due to limited improvement in current treatment strategies. In spite of aggressive PC research, for the past three decades, there has been no significant improvement in the five-year survival for this cancer. Like many other cancers, it takes several years for normal pancreatic cells to transform into pancreatic precursor lesions and to further progress into invasive carcinoma. Hence there is a scope for the development of chemo-preventive strategies to inhibit/ delay/prevent progression of this disease into an advanced stage cancer.
Objective: Chemoprevention of pancreatic cancer.
Method: Review of published literature.
Results and Conclusion: Availability of various genetically engineered mouse (GEM) models of PC has led to accelerated progress in understanding the disease and developing intervention strategies otherwise stalled for a long time. These GEM models spontaneously develop PC in a stepwise manner and mimic the disease etiology in humans. Understanding PC development from initiation to progression to metastasis is very important for early detection and prevention of PC. In this review, we focus on the current situation, the potential challenges, the progress in existing strategies and available opportunities as well as suggest key areas for research within the increasingly important area of pancreatic cancer chemoprevention.
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Cite this article as:
Current Challenges and Opportunities for Chemoprevention of Pancreatic Cancer, Current Medicinal Chemistry 2018; 25 (22) . https://dx.doi.org/10.2174/0929867324666170209104453
DOI https://dx.doi.org/10.2174/0929867324666170209104453 |
Print ISSN 0929-8673 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-533X |
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