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Review Article

乳酸脱氢酶抑制:生化相关性和治疗潜力

卷 26, 期 18, 2019

页: [3242 - 3252] 页: 11

弟呕挨: 10.2174/0929867324666170209103444

价格: $65

摘要

乳酸脱氢酶(LHD)是几乎所有生物体厌氧代谢的关键酶，也是糖异生和单链DNA代谢过程中葡萄糖恢复的功能检查点。这种酶在进化过程中以及在物种间具有良好的结构，氨基酸序列的变化很少，但有时非常有用，这使得它成为设计和构建能够调节其催化潜力和表达的功能分子的一个有吸引力的目标。目前对恶性疟原虫LDH同工酶(特别是LDH-5)和乳酸脱氢酶的研究主要集中在调节剂的选择上。本文综述了近年来抑制剂设计和开发的最新进展，指出了抑制剂的特异性和治疗潜力。

关键词: 乳酸脱氢酶、酶抑制剂、喹啉衍生物、草酸酯及其衍生物、加洛黄素、双功能抑制剂、miRNA和shRNAs。

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