分子运动在结核病药物开发：在细胞壁的另一个断裂

Title:Molecular Players in Tuberculosis Drug Development: Another Break in the Cell Wall

Volume: 24 Issue: 36

关键词: 结核病，药物，蛋白质结构，结核病药物开发，细胞壁，抗菌。

摘要: Tuberculosis is a leading killer, especially for people living with HIV. It is a real medical need to tackle this disease, which is made difficult to treat due to the increasing spread of multi-drug-resistant and extensively drug-resistant bacterial strains. Cases of tuberculosis that are resistant to virtually all drugs currently available are increasing at an alarming rate around the world. Here, we review the current knowledge in the field of drug development against tuberculosis with a focus on the mechanisms of action of drugs and the targeted bacterial cell processes involved. Particular emphasis is dedicated to the process of cell wall synthesis, which has proven to provide strong potentialities for drug development. It is hoped that a deeper understanding of key molecular machineries to tackle will provide us with a better outline of possible antibacterial mechanisms of action and offer hints for the design of more efficient strategies to treat resistant tuberculosis in the future.

Cite this article as:

Molecular Players in Tuberculosis Drug Development: Another Break in the Cell Wall, Current Medicinal Chemistry 2017; 24 (36) . https://dx.doi.org/10.2174/0929867324666170208150016