Abstract
Background: The design and performing of cascade reactions is a challenging but stimulating and interesting facet of organic synthesis, yet one that can convey conspicuous novelty, efficiency as well as elegance and sophistication to synthetic approaches. On the other hand, isocyanides are well-recognized as privileged synthons in the synthesis of a wide range of heterocycles.
Objective: In this review, we try to illustrate the power, efficiency, and convenience of combining cascade process as an expedient strategy with versatility of isocyanide-based multicomponent reactions in the synthesis of aza-heterocycles from 1993 till date. Comprising isocyanides in cascade or sequential pathway also represents a milestone in combinatorial chemistry which is a bounce for this contented marriage.Keywords: Isocyanides, isonitriles, cascade reactions, tandem reactions, domino reactions, ugi reactions, aza-heterocyclic compounds.
Graphical Abstract
Call for Papers in Thematic Issues
Catalytic C-H bond activation as a tool for functionalization of heterocycles
The major topic is the functionalization of heterocycles through catalyzed C-H bond activation. The strategies based on C-H activation not only provide straightforward formation of C-C or C-X bonds but, more importantly, allow for the avoidance of pre-functionalization of one or two of the cross-coupling partners. The beneficial impact of ...read more
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