Abstract
Background: The quinoline moiety has been reported to be a privileged structure due to its presence in many drugs. It appears in alkaloids and natural products such as quinine, camptothecin or cinchonidine. The spectrum of the activity of quinoline-related compounds includes not only antimicrobial but also anticancer effects.
Objective: Those active quinoline alkaloids have become the basis for a large number of synthetic drugs.Nowadays, more than a third of quinoline-derived drugs have a natural provenance. There are also a number of quinoline alkaloids that have been used extensively for treating neglected diseases in traditional medicine. Interestingly, most of the active plants predominantly populate countries that suffer most from such diseases. In this work, quinoline alkaloids that have an antimicrobial activity that might be relevant to neglected diseases are reviewed.
Keywords: Quinolines, neglected diseases, alkaloids, antimicrobial, anticancer, quinoline derived drugs.
Graphical Abstract
Call for Papers in Thematic Issues
Catalytic C-H bond activation as a tool for functionalization of heterocycles
The major topic is the functionalization of heterocycles through catalyzed C-H bond activation. The strategies based on C-H activation not only provide straightforward formation of C-C or C-X bonds but, more importantly, allow for the avoidance of pre-functionalization of one or two of the cross-coupling partners. The beneficial impact of ...read more
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