Surrogates of Insulin Sensitivity and Indices of Cardiometabolic Profile in Obesity

Title:Surrogates of Insulin Sensitivity and Indices of Cardiometabolic Profile in Obesity

Volume: 15 Issue: 4

Author(s): Djordje S. Popovic*, Edita Stokic, Milena Mitrovic, Dragana Tomic-Naglic, Radoslav Pejin, Tijana Icin, Bojan Vukovic, Zeljko Zivanovic, Sladjana Pejakovic and Branka Kovacev-Zavisic

Affiliation:

• Clinic for Endocrinology, Diabetes and Metabolic Disorders, Clinical Center of Vojvodina, Medical Faculty, University of Novi Sad, Hajduk Veljkova 1, 21000 Novi Sad,Serbia

Keywords: Adiponectin, adipose tissue, atherosclerosis, insulin resistance, insulin sensitivity, metabolic syndrome, nonalcoholic fatty liver disease, obesity.

Abstract: Background and Objectives: Obesity is often associated with insulin resistance (IR). We considered different IR indexes: the Homeostasis Model Assessment-Insulin Resistance (HOMA-IR) index, the two specimen (0 and 120 min) oral glucose tolerance test Matsuda Index (MI) and the Homeostasis Model Assessment-Adiponectin (HOMA-AD) index. These IR indexes were compared with indicators of the cardiometabolic profile.

Method: This cross-sectional study enrolled 60 obese individuals without previous history of diabetes. Anthropometrical, ultrasound and laboratory examinations were conducted.

Results: All 3 indexes significantly correlated with indicators of central obesity, systolic and diastolic blood pressure, inflammation parameters, liver enzymes, HbA1c and some lipid parameters. The majority of correlation coefficients were the highest for HOMA-AD, but only the difference in correlation with waist circumference comparing with MI was statistically significant. HOMA-IR directly, and MI indirectly, significantly correlated with age, while HOMA-AD significantly directly correlated with the mean carotid artery intima media thickness (CAIMT). MI showed the best performances in predicting non-alcoholic fatty liver disease and pathologically increased CAIMT; HOMA-AD was the best in predicting metabolic syndrome, while HOMA-IR demonstrated the poorest performances in the prediction of all 3 conditions. There were no statistically significant differences in predicting performances of the analysed indexes.

Conclusion: The HOMA-AD and MI are not superior compared with the HOMA-IR, in the identification of obese individuals with a proatherogenic cardiometabolic profile.

Cite this article as:

Popovic S. Djordje*, Stokic Edita, Mitrovic Milena, Tomic-Naglic Dragana, Pejin Radoslav, Icin Tijana, Vukovic Bojan, Zivanovic Zeljko, Pejakovic Sladjana and Kovacev-Zavisic Branka, Surrogates of Insulin Sensitivity and Indices of Cardiometabolic Profile in Obesity, Current Vascular Pharmacology 2017; 15 (4) . https://dx.doi.org/10.2174/1570161115666170202160948

DOI https://dx.doi.org/10.2174/1570161115666170202160948	Print ISSN 1570-1611
Publisher Name Bentham Science Publisher	Online ISSN 1875-6212