药物从人血清白蛋白中的位移：从分子相互作用到临床意义

Title:Displacement of Drugs from Human Serum Albumin: From Molecular Interactions to Clinical Significance

Volume: 24 Issue: 18

关键词: 人血清白蛋白，药物置换，药代动力学相互作用，游离浓度，药物设计

摘要: Background: Human serum albumin (HSA) is the most abundant protein in human serum. It has numerous functions, one of which is transport of small hydrophobic molecules, including drugs, toxins, nutrients, hormones and metabolites. HSA has the ability to interact with a wide variety of structurally different compounds. This promiscuous, nonspecific affinity can lead to sudden changes in concentrations caused by displacement, when two or more compounds compete for binding to the same molecular site.

Cite this article as:

Displacement of Drugs from Human Serum Albumin: From Molecular Interactions to Clinical Significance, Current Medicinal Chemistry 2017; 24 (18) . https://dx.doi.org/10.2174/0929867324666170202152134