摘要
背景:星形胶质细胞有助于伴随神经退行性疾病如阿尔茨海默病(AD)的炎症反应。从这个意义上说,这些疾病的毒性可能通过调节星形胶质细胞炎症反应而减弱。最近的cd300f免疫受体被称为提示的免疫受体家族的新成员,具有良好的调节性能。 目的:在这里,我们研究的是过度的hcd300f(的cd300f人类亚型)在星形胶质细胞的保护海马神经元再次ST的β淀粉样蛋白诱导的变性(一β)低聚物。 方法:转染星形胶质细胞膜hcd300f播种前海马神经元共培养,然后暴露于β1-42低聚物(5μm,48h。) 结果:hcd300f表达明显被β引起的神经元的损失。这种效应依赖于神经元-星形胶质细胞与细胞间的相互作用,因为使用转基因星形胶质细胞的条件培养基没有观察到保护作用。星形胶质细胞的调节依赖于胞内的信号hcd300f尾。此外hcd300f表达不影响星形胶质细胞的摄取β1 - 42聚体的内吞能力,丢弃的可能性,增加了β1-42间隙可以通过hcd300f介导的神经保护作用。 结论:这些结果表明,星形胶质细胞的hcd300f免疫受体直接表达可以在AD的神经保护策略。
关键词: 阿尔茨海默病,淀粉样蛋白,星形胶质细胞,cd300f,神经保护,内吞。
Current Alzheimer Research
Title:Astrocytic Expression of the Immunoreceptor CD300f Protects Hippocampal Neurons from Amyloid-β Oligomer Toxicity In Vitro
Volume: 14 Issue: 7
关键词: 阿尔茨海默病,淀粉样蛋白,星形胶质细胞,cd300f,神经保护,内吞。
摘要: Background: Astrocytes contribute to neuroinflammation that accompanies neurodegenerative disorders such as Alzheimer’s disease (AD). In this sense, the toxicity of these diseases might be attenuated through the modulation of astrocytic inflammatory responses. Recently, the CD300f immunoreceptor was described as a new member of the CD300 immunoreceptor family, showing promising modulatory properties.
Objective: Here, we investigated whether overexpression of hCD300f (the human isoform of CD300f) in astrocytes protects hippocampal neurons against the degeneration induced by amyloid-beta (Aβ) oligomer. Method: Astrocyte monolayers were transfected with hCD300f before seeding the hippocampal neurons, and then the co-culture was exposed to Aβ1-42 oligomers (5 μM, 48h). Results: hCD300f expression significantly abrogated the neuronal loss elicited by Aβ. This effect was dependent on neuron-astrocyte cell-cell interactions since no protection was observed using conditioned media from transfected astrocytes. Astrocyte modulation was dependent on the cytoplasmic signaling tail of hCD300f. Furthermore hCD300f expression did not affect the ability of astrocytes to uptake Aβ1- 42 oligomers by endocytosis, which discards the possibility that increased Aβ1-42 clearance could mediate neuroprotection by hCD300f. Conclusion: These results suggest that the astrocyte-directed expression of the hCD300f immune receptor can be a neuroprotective strategy in AD disease.Export Options
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Cite this article as:
Astrocytic Expression of the Immunoreceptor CD300f Protects Hippocampal Neurons from Amyloid-β Oligomer Toxicity In Vitro, Current Alzheimer Research 2017; 14 (7) . https://dx.doi.org/10.2174/1567205014666170202121709
DOI https://dx.doi.org/10.2174/1567205014666170202121709 |
Print ISSN 1567-2050 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5828 |
Call for Papers in Thematic Issues
Current updates on the Role of Neuroinflammation in Neurodegenerative Disorders
Neuroinflammation is an invariable hallmark of chronic and acute neurodegenerative disorders and has long been considered a potential drug target for Alzheimer?s disease (AD) and dementia. Significant evidence of inflammatory processes as a feature of AD is provided by the presence of inflammatory markers in plasma, CSF and postmortem brain ...read more
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