Microwave-induced Triazole Synthesis via 1,3-dipolar azide-alkyne cycloaddition: Recent Advances

Title:Microwave-induced Triazole Synthesis via 1,3-dipolar azide-alkyne cycloaddition: Recent Advances

Volume: 3 Issue: 3

Author(s): Sujit Ghosh and Basudeb Basu*

Affiliation:

• Department of Chemistry, North Bengal University, Darjeeling 734 013,India

Keywords: Azide-alkyne cycloaddition (AAC), microwave irradiation (MW), 1, 2, 3-triazole, regioisomer, copper catalyst, metal-free, triazole synthesis.

Abstract: Background: 1,3-Dipolar azide-alkyne cycloaddition (AAC) reaction, often referred to as click reaction, is an expeditious and robust protocol for the construction of triazole derivatives. In most cases, the reaction is catalyzed by a copper catalyst.

Methods: Non-conventional microwave heating has been used for the reaction showing ample advantages over the conventional thermal heating.

Conclusion: This article has presented an overview on the recent advances in the area of microwave- induced AAC reactions in the presence of both homogeneous and heterogeneous copper catalysts, besides a few examples of Ru-catalyzed as well as metal-free AAC reactions.

Cite this article as:

Ghosh Sujit and Basu Basudeb*, Microwave-induced Triazole Synthesis via 1,3-dipolar azide-alkyne cycloaddition: Recent Advances, Current Green Chemistry 2016; 3 (3) . https://dx.doi.org/10.2174/2213346104666170130143600

DOI https://dx.doi.org/10.2174/2213346104666170130143600	Print ISSN 2213-3461
Publisher Name Bentham Science Publisher	Online ISSN 2213-347X