Synthesis, Properties, and Mechanism of Action of New Generation of Polycyclic Glycopeptide Antibiotics

Title:Synthesis, Properties, and Mechanism of Action of New Generation of Polycyclic Glycopeptide Antibiotics

Volume: 17 Issue: 19

Author(s): Eugenia N. Olsufyeva and Anna N. Tevyashova*

Affiliation:

• Laboratory of Chemical Transformation of Antibiotics, Gause Institute of New Antibiotics, P.O. Box: 119021, 11 B. Pirogovskaya, Moscow,Russian Federation

Keywords: Glycopeptide antibiotics, Drug resistance, Mechanism of action, Semisynthetic derivatives, Vancomycin.

Abstract: Introduction: The increased resistance of glycopeptide based antibiotics has become a serious problem for the chemotherapy of infections triggered by resistant Gram-positive bacteria. This has motivated the urgent sincere efforts to develop potent glycopeptide-based antibiotics in both academy and industry research laboratories. Understanding of the mechanism of action of natural and modified glycopeptides is considered as the basis for the rational design of compounds with valuable properties to achieve the fundamental results. Several hydrophobic glycopeptide analogues active against resistant strains were developed during the last two decades. Three drugs, namely, oritavancin, telavancin and dalbavancin were approved by FDA in 2013-2014. It was found that hydrophobic derivatives act through different mechanisms without binding with the modified target of resistant bacteria.

Cite this article as:

Olsufyeva N. Eugenia and Tevyashova N. Anna*, Synthesis, Properties, and Mechanism of Action of New Generation of Polycyclic Glycopeptide Antibiotics, Current Topics in Medicinal Chemistry 2017; 17 (19) . https://dx.doi.org/10.2174/1568026617666170130115957