Calcium Dependent Protein Kinases (CDPKs): Key to Malaria Eradication

Title:Calcium Dependent Protein Kinases (CDPKs): Key to Malaria Eradication

Volume: 17 Issue: 19

Author(s): Kavita Kadian, Yash Gupta, Prakasha Kempaiah, Nikesh Gupta, Arun Sharma and Manmeet Rawat*

Affiliation:

• Department of Internal Medicine, University of New Mexico School of Medicine, Health Sciences Center, MSC10-5550, Albuquerque, NM87131-0001,United States

Keywords: CDPK, Calcium signalling, Plasmodium parasites, drug target, Malaria, CDPK.

Abstract: Introduction: The family of calcium-dependent protein kinases (CDPKs) carries a kinase domain fused to a calmodulin-like domain. The presence of protein kinases devoid of clear mammalian eukaryotic protein kinase orthologues makes them potential targets for therapeutic development. Recent studies on CDPKs have inspired an important primary regulator of calcium (intracellular Ca2+ signaling), which is extensively reported to play a critical role in various stages of the apicomplexan life cycle such as microneme secretion of adhesions, cell invasion, gamete maturation, gliding motility and egress of Plasmodium Spp.

Cite this article as:

Kadian Kavita, Gupta Yash, Kempaiah Prakasha, Gupta Nikesh, Sharma Arun and Rawat Manmeet*, Calcium Dependent Protein Kinases (CDPKs): Key to Malaria Eradication, Current Topics in Medicinal Chemistry 2017; 17 (19) . https://dx.doi.org/10.2174/1568026617666170130112714