Exploring 1,3,4-Oxadiazole Scaffold for Anti-inflammatory and Analgesic Activities: A Review of Literature From 2005-2016

Title:Exploring 1,3,4-Oxadiazole Scaffold for Anti-inflammatory and Analgesic Activities: A Review of Literature From 2005-2016

Volume: 18 Issue: 3

Author(s): Gita Chawla*, Baby Naaz and Anees A. Siddiqui

Affiliation:

• Department of Pharmaceutical Chemistry, School of Pharmaceutical Education and Research, Jamia Hamdard (Hamdard University), Hamdard Nagar, New Delhi 110062,India

Keywords: Analgesic, anti-inflammatory, scaffold, COX, 1, 3, 4-Oxadiazole, NSAIDs.

Abstract: 1,3,4-Oxadiazole derivatives are found to have a wide range of pharmacological activities and attracting the researchers to work on this nucleus. Literature survey indicates that many 1,3,4- oxadiazoles have been synthesized with the aim to get compounds of significant anti-inflammatory and analgesic activities with reduced adverse effects. The purpose of this review is to compile the reports on 1,3,4-oxadiazole derivatives possessing anti-inflammatory and analgesic activities. The review also includes the reports on 1,3,4-oxadiazole derivatives of existing NSAIDs in the last ten years.

Cite this article as:

Chawla Gita*, Naaz Baby and Siddiqui A. Anees, Exploring 1,3,4-Oxadiazole Scaffold for Anti-inflammatory and Analgesic Activities: A Review of Literature From 2005-2016, Mini-Reviews in Medicinal Chemistry 2018; 18 (3) . https://dx.doi.org/10.2174/1389557517666170127121215