摘要
背景:尽管阿尔茨海默病(AD)是一种神经变性病理学特征,其特征在于脑水平上β-淀粉样蛋白斑块和神经原纤维缠结的积累,但最近的研究表明,AD可能是许多改变的生理过程在整个生物体水平发生的结果。通过“弯曲”而不是“打破”适应压力的能力可以被认为是“弹性”。个体倾向于抵抗这种病理生理挑战,可以认为比那些不具有这些挑战的人更有弹性。值得注意的是,最近的文献提供了AD运动诱发的积极效应的证据,包括改善脑可塑性,增加肾上腺敏感性,增加血管健康,改善一氧化氮生物利用度和线粒体功能。本综述探讨了AD环境中的恢复力意味着什么以及身体活动可能会调解增强韧性的积极适应过程的生理机制。 方法:进行综合的PubMed搜索,以确定关于运动在AD弹性中的作用的研究。应用以下术语:阿尔茨海默病弹性,脑回弹力,代谢弹性,心血管恢复力,线粒体弹性和运动弹性。 结果:纳入73项研究。五篇论文定义了阿尔茨海默病的弹性,15篇论文的脑回弹力,5个心血管复原力,1个代谢弹性,11个线粒体弹性和7个运动弹性。其他二十六份文件从作者知识参考清单中确定。 结论:知道脑,神经内分泌,血管和线粒体代谢紊乱是神经退行性疾病和痴呆发育中的重要事件,运动诱发适应性机制的能力可能是改善AD抵抗能力的重要非药理学策略。
关键词: 阿尔茨海默病,运动,脑弹性,神经内分泌恢复力,心血管弹性,线粒体弹性。
Current Alzheimer Research
Title:Resilience to Alzheimer's Disease: The Role of Physical Activity
Volume: 14 Issue: 5
关键词: 阿尔茨海默病,运动,脑弹性,神经内分泌恢复力,心血管弹性,线粒体弹性。
摘要: Background: Although Alzheimer’s disease (AD) is a neurodegenerative pathology characterized by accumulation of β-amyloid plaques and neurofibrillary tangles at cerebral level, recent studies highlighted that AD might be the result of many altered physiological processes occurring at whole-organism level. The ability to adapt to stressors by “bending” but not “breaking” can be considered as “resilience”. Individuals incline to withstand such pathophysiological challenges, can be considered more resilient than those that do not. Noticeably, recent literature provide evidence of several exercise-induced positive effects in AD patients including improved brain plasticity, increased adrenal sensitivity, increased vascular health, ameliorations of nitric oxide bioavailability and mitochondrial function. This review explores what resilience means in the AD milieu and the physiological mechanisms by which physical activity may mediate positive adaptative processes that enhance resilience.
Methods: A comprehensive PubMed search was conducted to identify studies about the role of exercise in AD resiliency. The following terminology was applied: Alzheimer resilience, brain resilience, metabolic resilience, cardiovascular resilience, mitochondrial resilience and exercise resilience. Results: Seventy-three studies were included. Five papers defined Alzheimer’s resilience, 15 papers brain resilience, 5 cardiovascular resilience, 1 metabolic resilience, 11 mitochondrial resilience, and 7 exercise resilience. Other twenty-six paper were identified from reference list of authors’ knowledge. Conclusion: Knowing that disturbances in brain, neuroendocrine, vascular and mitochondria metabolism are important events in neurodegeneration and dementia development, the ability of exercise to trigger adaptive mechanisms might represent an important non-pharmacological strategy to improve resilience to AD.Export Options
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Cite this article as:
Resilience to Alzheimer's Disease: The Role of Physical Activity, Current Alzheimer Research 2017; 14 (5) . https://dx.doi.org/10.2174/1567205014666170111145817
DOI https://dx.doi.org/10.2174/1567205014666170111145817 |
Print ISSN 1567-2050 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5828 |
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Current updates on the Role of Neuroinflammation in Neurodegenerative Disorders
Neuroinflammation is an invariable hallmark of chronic and acute neurodegenerative disorders and has long been considered a potential drug target for Alzheimer?s disease (AD) and dementia. Significant evidence of inflammatory processes as a feature of AD is provided by the presence of inflammatory markers in plasma, CSF and postmortem brain ...read more
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