Abstract
Human osteoarthritis (OA) is a complex multi-factorial disease that primarily targets the cartilage. The cartilage is a specialized tissue where the chondrocytes maintain matrix homeostasis. The paradigm for the post genomic era of molecular medicine is to identify the function of defective genes associated with specific diseases. Although the process of identification and validation of target genes is feasible with the available tools and technologies, establishing the link between defected gene products and the disease is still a challenging task. New tools in genomic analysis not only allow us to profile gene expression in normal and diseased tissues, but also facilitate the development of unbiased hypothesis at the molecular level. Several defective heritable genes encoding the matrix components (such as Col2a1 and Col9a1 that code for type II and IX collagen respectively) have been linked to the development of OA in human and animal models. Several families of genes expressed differentially in normal and osteoarthritis-affected cartilage have been identified. These include matrix metalloproteinases (MMPs), matrix proteins, integrins, transcription factors, cytokines, cytokine receptors, growth factors and homeostatic genes. A non-conventional functional genomic approach is required to study the complexity of chondrocyte and matrix interactions that affect the above mentioned targets.
Keywords: osteoarthritis, human osteoarthritis, matrix protein, oa, integrin, metalloproteinase
Current Genomics
Title: Gene Mining and Functional Genomics in Human Osteoarthritis
Volume: 4 Issue: 2
Author(s): M. G. Attur, M. N. Dave and A. R. Amin
Affiliation:
Keywords: osteoarthritis, human osteoarthritis, matrix protein, oa, integrin, metalloproteinase
Abstract: Human osteoarthritis (OA) is a complex multi-factorial disease that primarily targets the cartilage. The cartilage is a specialized tissue where the chondrocytes maintain matrix homeostasis. The paradigm for the post genomic era of molecular medicine is to identify the function of defective genes associated with specific diseases. Although the process of identification and validation of target genes is feasible with the available tools and technologies, establishing the link between defected gene products and the disease is still a challenging task. New tools in genomic analysis not only allow us to profile gene expression in normal and diseased tissues, but also facilitate the development of unbiased hypothesis at the molecular level. Several defective heritable genes encoding the matrix components (such as Col2a1 and Col9a1 that code for type II and IX collagen respectively) have been linked to the development of OA in human and animal models. Several families of genes expressed differentially in normal and osteoarthritis-affected cartilage have been identified. These include matrix metalloproteinases (MMPs), matrix proteins, integrins, transcription factors, cytokines, cytokine receptors, growth factors and homeostatic genes. A non-conventional functional genomic approach is required to study the complexity of chondrocyte and matrix interactions that affect the above mentioned targets.
Export Options
About this article
Cite this article as:
Attur G. M., Dave N. M. and Amin R. A., Gene Mining and Functional Genomics in Human Osteoarthritis, Current Genomics 2003; 4 (2) . https://dx.doi.org/10.2174/1389202033350056
DOI https://dx.doi.org/10.2174/1389202033350056 |
Print ISSN 1389-2029 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5488 |
Call for Papers in Thematic Issues
Current Genomics in Cardiovascular Research
Cardiovascular diseases are the main cause of death in the world, in recent years we have had important advances in the interaction between cardiovascular disease and genomics. In this Research Topic, we intend for researchers to present their results with a focus on basic, translational and clinical investigations associated with ...read more
Deep learning in Single Cell Analysis
The field of biology is undergoing a revolution in our ability to study individual cells at the molecular level, and to integrate data from multiple sources and modalities. This has been made possible by advances in technologies for single-cell sequencing, multi-omics profiling, spatial transcriptomics, and high-throughput imaging, as well as ...read more
New insights on Pediatric Tumors and Associated Cancer Predisposition Syndromes
Because of the broad spectrum of children cancer susceptibility, the diagnosis of cancer risk syndromes in children is rarely used in direct cancer treatment. The field of pediatric cancer genetics and genomics will only continue to expand as a result of increasing use of genetic testing tools. It's possible that ...read more
Related Journals
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Tamoxifen in the Treatment of Hepatocellular Carcinoma: 5-Year Results of the CLIP-1 Multicentre Randomised Controlled Trial
Current Pharmaceutical Design Bacterial Adaptation and Infection
Inflammation & Allergy - Drug Targets (Discontinued) Patent Annotations
Recent Patents on Inflammation & Allergy Drug Discovery Neuroprotection with Natural Antioxidants and Nutraceuticals in the Context of Brain Cell Degeneration: The Epigenetic Connection
Current Topics in Medicinal Chemistry Possible Neuroprotective Strategies in ALS
Current Neuropharmacology US Guided Treat-to-Target Approach in Early RA: Implications for Uncoupling of Disease Activity and Structural Joint Damage
Current Rheumatology Reviews Biomarkers for VEGF-Targeted Therapy in Renal Cell Carcinoma: Critical Review of Level of Evidence and Up to Date
Recent Patents on Biomarkers Understanding Nutritional Interventions and Physical Exercise in Non-Alcoholic Fatty Liver Disease
Current Molecular Medicine Betulinic Acid as a Potent and Complex Antitumor Phytochemical: A Minireview
Anti-Cancer Agents in Medicinal Chemistry Docking Studies, Synthesis and Biological Evaluation of β-aryl-β-hydroxy Propanoic Acids for Anti-inflammatory Activity
Medicinal Chemistry Oxaliplatin Regulates Chemotherapy Induced Peripheral Neuropathic Pain in the Dorsal Horn and Dorsal Root Ganglion via the Calcineurin/NFAT Pathway
Anti-Cancer Agents in Medicinal Chemistry Functional Immunoregulation by Heme Oxygenase 1 in Juvenile Autoimmune Diseases
Current Gene Therapy A New Role for Zn(II) Aminopeptidases: Antigenic Peptide Generation and Destruction
Current Pharmaceutical Design Novel Promising Therapeutic Agents in Multiple Sclerosis
Recent Patents on Inflammation & Allergy Drug Discovery Guanylate Cyclase C: A Current Hot Target, from Physiology to Pathology
Current Medicinal Chemistry Mesenchymal Stem Cells: Key Actors in Tumor Niche
Current Stem Cell Research & Therapy L-Cysteine Catalyzed Environmentally Benign One-pot Multicomponent Approach Towards the Synthesis of Dihydropyrano[2,3-c]pyrazole Derivatives
Current Organic Synthesis Editorial (Thematic Issue: Novel Targets and Biomarkers for Anti-atherosclerotic Therapy)
Current Pharmaceutical Design A Role of the 9-Aminoacridines and their Conjugates in a Life Science
Current Protein & Peptide Science Eosinophils, a Jack of All Trades in Immunity: Therapeutic Approaches for Correcting Their Functional Disorders
Endocrine, Metabolic & Immune Disorders - Drug Targets