Tretinoin Loaded Nanostructured Lipid Carrier (NLC): Safe and Effective Drug Delivery System

Title:Tretinoin Loaded Nanostructured Lipid Carrier (NLC): Safe and Effective Drug Delivery System

Volume: 7 Issue: 2

Author(s): Azadeh Moradi, Effat Sadat Farboud, Saman Ahmad Nasrollahi*, Mansour Nassiri Kashani and Rasoul Dinarvand

Affiliation:

• Center for Research & Training in Skin Diseases & Leprosy (CRTSDL), Tehran University of Medical Sciences (TUMS), # 415 Taleqani Ave, Tehran,Iran

Keywords: Tretinoin, nanostructured lipid carriers, high pressure homogenizer, safety, atomic force microscopy, morphology.

Abstract: Background and Aim: Tretinoin has been formulated in different vehicles in an attempt to decrease the irritation associated with the past formulations. So to improve the skin uptake and reduce irritation of tretinoin, we need a carrier with an ability of skin targeting. For achieving this purpose, nanostructured lipid carriers (NLCs) are chosen as a new topical drug delivery system to improve the absorption and reduce side effects.

Method: Cetyl alcohol and isopropyl myristate was selected as the lipid of NLC. Polysorbate 80 was used as the surfactants to stabilize NLC. The hot homogenization method was performed to prepare the tretinoin loaded NLC. The various formulations were characterized by photon correlation spectroscopy. Atomic Force Microscopy and Transmission Electron Microscopy were used to study particle morphology. Drug entrapment efficiency and safety of the drug delivery system were examined.

Result: The results indicated almost the full loading of tretinoin in the NLC and the validity of the production method. The in vitro release studies demonstrated that the product was a slow- release one which affects reducing side effects and improves the effectiveness of tretinoin. Human patch test of tretinoin loaded NLC was done and the result was completely safe.

Conclusion: The in vitro release studies showed that NLC containing tretinoin has prolonged profile as compared to commercially available tretinoin creams. It appears that the prolong release profile sustains permeation and absorption of tretinoin and also provides skin tolerability.

Cite this article as:

Moradi Azadeh, Farboud Sadat Effat, Nasrollahi Ahmad Saman*, Kashani Nassiri Mansour and Dinarvand Rasoul, Tretinoin Loaded Nanostructured Lipid Carrier (NLC): Safe and Effective Drug Delivery System, Nanoscience & Nanotechnology-Asia 2017; 7 (2) . https://dx.doi.org/10.2174/2210681207666170102141907

DOI https://dx.doi.org/10.2174/2210681207666170102141907	Print ISSN 2210-6812
Publisher Name Bentham Science Publisher	Online ISSN 2210-6820