摘要
背景:参与不同生理过程和信号通路的天冬氨酰蛋白内蛋白酶之一的组织蛋白酶D(CATD)对细胞内蛋白质的代谢分解,酶的生长因子,激素和前体的活化,抗原的加工,酶抑制剂和活化剂以及细胞凋亡的调控均有作用。 作为目标的意义:研究已经证实了CATD在诸如动脉粥样硬化,阿尔茨海默病,癌症,心血管,亨廷顿和帕金森病等病理状况的作用和意义。合并和遮蔽为无活性的proCATD,它经历不同的切割,以在酸性环境中达到所需的构象,起到功能活性蛋白质的作用。为了寻找新的癌症候选靶点,CATD已经吸引了全球范围内广泛的研究人员,并被公认为癌症特别是乳腺和激素依赖性癌症的明确标志物。 方法:本综述中,PubMed,Sci-finder等搜索引擎用于收集组织蛋白酶D的信息。彻底研究了必要的相关信息,使本文适用于突出与组织蛋白酶D相关的所有方面及其作用癌症。 结论与结论:本研究除了综述天然产物在癌症化学预防中靶向CATD的益处,还涉及CATD在癌症中的结构,功能和调节方面,其在血管生成,转移,侵袭,凋亡,细胞增殖和治疗潜力中的重要作用,。
关键词: 天冬氨酸蛋白酶,癌症,组织蛋白酶D,化学预防,天然产物,细胞凋亡。
图形摘要
Current Cancer Drug Targets
Title:Cathepsin D as a Promising Target for the Discovery of Novel Anticancer Agents
Volume: 17 Issue: 5
关键词: 天冬氨酸蛋白酶,癌症,组织蛋白酶D,化学预防,天然产物,细胞凋亡。
摘要: Background: Cathepsin D (CATD), one of the aspartyl endoproteinase involved in different physiological processes and signaling pathways, is accountable for metabolic breakdown of intracellular proteins, the activation of growth factors, hormones, and precursors of enzyme, the processing of antigens, enzyme inhibitors and activators and the regulation of apoptosis.
Implication as a Target: Studies have confirmed the role and significance of CATD in an assortment of pathological conditions like Atherosclerosis, Alzheimer, Cancer, Cardiovascular, Huntington and Parkinson diseases. Amalgamated and veiled as inactive proCATD, it undergoes diverse cleavages to attain a desired conformation in an acidic milieu to act as a functionally active protein. In search of new candidate target (s) for cancer, CATD has attracted a wide group of investigators across the globe and is being recognized as a well-defined marker in cancer especially for breast and hormone-dependent cancer. Methods: In this review, PubMed, Sci-finder and other search engines were used to gather information on Cathepsin D. The necessary and relevant information was thoroughly studied to make the article appropriate to highlight all the aspects related to Cathepsin D and its role in cancer. Findings & Conclusion: The present review illustrates structural, functional and regulatory aspects of CATD in cancer, its significant role in angiogenesis, metastasis, invasion, apoptosis, cell proliferation, and therapeutic potential besides the benefits of targeting CATD by the natural products in cancer chemoprevention.Export Options
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Cite this article as:
Cathepsin D as a Promising Target for the Discovery of Novel Anticancer Agents, Current Cancer Drug Targets 2017; 17 (5) . https://dx.doi.org/10.2174/1568009616666161229145115
DOI https://dx.doi.org/10.2174/1568009616666161229145115 |
Print ISSN 1568-0096 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-5576 |
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