摘要
耐药性和治疗失败是疾病复发和进展的重要原因,可能被认为是阻止癌症患者治愈的主要障碍。 肿瘤使用大量的分子生化和细胞机制来逃避化疗和靶向治疗。 药物功效的重要决定因素是可能在很大程度上受肿瘤生理学影响的药物的内在药理学特征。 实体肿瘤的一个特征是酸性细胞外pH,由代谢转移和增加的代谢率与由于缺血性血管系统的低组织灌注相结合。 除了在促进肿瘤生长和转移的肿瘤病理生物学中的作用之外,酸性肿瘤环境为许多抗癌药物产生化学屏障,从而限制了其活性。 本综述的内容将重点放在肿瘤酸中毒的病理生理学及其在治疗中的作用。
关键词: 癌症,耐药性,肿瘤酸中毒,离子捕获,通透性,pKa ..
Current Medicinal Chemistry
Title:Pathobiology and Therapeutic Implications of Tumor Acidosis
Volume: 24 Issue: 26
关键词: 癌症,耐药性,肿瘤酸中毒,离子捕获,通透性,pKa ..
摘要: Drug resistance and therapeutic failure are important causes of disease relapse and progression and may be considered as major obstacles preventing cure of cancer patients. Tumors use a large number of molecular, biochemical and cellular mechanisms to evade chemotherapy and targeted therapy. Important determinants of drug efficacy are the intrinsic pharmacological characteristics of drugs which may be largely affected by the tumor physiology. One feature of solid tumors is the acidic extracellular pH, resulting from metabolic shift and increased metabolic rates combined with low tissue perfusion due to defective vasculature. Besides its role in tumor pathobiology promoting tumor growth and metastasis, the acidic tumor environment creates a chemical barrier for many anticancer drugs, thus limiting their activity. The content of this review will be focused on the pathobiology of tumor acidosis and on its role in therapeutic resistance.
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Cite this article as:
Pathobiology and Therapeutic Implications of Tumor Acidosis, Current Medicinal Chemistry 2017; 24 (26) . https://dx.doi.org/10.2174/0929867323666161228142849
DOI https://dx.doi.org/10.2174/0929867323666161228142849 |
Print ISSN 0929-8673 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-533X |
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